摘要
目的:研究外周血中中性粒细胞与淋巴细胞比值(NLR)在多发性骨髓瘤(MM)患者预后中的价值。方法:回顾性分析88例初诊MM患者的临床资料,将MM患者分为高NLR组与低NLR组,分析两组患者在血红蛋白(Hb)、血清钙离子(Ca)、血清β2微球蛋白(β2-MG)、血清白蛋白(ALB)、血清肌酐(Cr)、国际分期标准(ISS)和总体生存期(OS)方面的差异。结果:与低NLR组相比,高NLR组血清β2-MG偏高、Cr偏高、Ca偏高、ISS分期偏晚、OS短,差异均有统计学意义(P<0.05)。结论:MM患者外周血中NLR升高提示预后不良,NLR与血清β2-MG、Cr等指标相结合,对于MM患者的预后评估有重要的意义。
Objective： To study the value of neutrophil to lymphocyte ratio（NLR） in the prognosis of patients with multiple myeloma（MM）. Methods： The clinical data of 88 newly diagnosed MM patients were analyzed retrospectively.MM patients were divided into high NLR group and low NLR group.The hemoglobin（Hb）,serum calcium（Ca）,serum β2 microglobulin,albumin（ALB）,serum creatinine（Cr）,international staging criteria（ISS） and overall survival（OS） were analyzed. Results： There were statistically significant differences in the expression of β2-MG,Ca and Cr between high NLR group and low NLR group（ P〈0.05）.There were also statistically significant differences in the ISS,over survival between high NLR group and low NLR group（ P〈0.05）. Conclusion： NLR combination with β2-MG,Cr and Ca can provide important value to evaluate the prognosis of MM patients.
作者
唐元艳
张利铭
张江召
熊涛
梁艳
余卓君
刘荟敏
刘敏
黄知平
Tang Yuanyan;Zhang Liming;Zhang Jiangzhao;Xiong Tao;Liang Yan;Yu Zhuojun;Liu Huimin;Liu Min;Huang Zhiping(Department of Hematology,Jingzhou Central Hospital,Affiliated to Tongji Medical College of Huazhong Science and Technology University,Hubei Jingzhou 434020,China)
出处
《现代肿瘤医学》
CAS
2018年第12期1899-1901,共3页
Journal of Modern Oncology
