摘要
目的分析肝、肾功能及血脂指标与急性脑梗死预后的相关性。方法选择100例急性脑梗死住院患者,所有患者于入院次日清晨采血检测血清尿酸(UA)、血肌酐(Scr)、血清三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、血钙(Ca^(2+))、空腹血糖(FPG)、纤维蛋白原(FIB)、D-二聚体(D-D)、血清同型半胱氨酸(Hcy)、总胆红素(TBIL)、直接胆红素(DBIL)、间接胆红素(IBIL)水平。根据CSS评分将入选患者分为轻型组(0~15分,35例)、中型组(16~30分,34例)、重型3组(31~45分,31例)。计算患者入院时与发病3个月时的NIHSS评分差值,根据NIHSS评分将患者分为好转组(评分差值>0分,58例)、无变化组(评分差值=0分,36例)与恶化组(评分差值<0分,6例)。比较不同病情轻重程度及不同预后患者的血清UA、Scr、TG、TC、LDL-C、HDL-C、Ca^(2+)、FPG、FIB、D-D、Hcy、TBIL、DBIL、IBIL,并分析相关性。结果重型组UA、Hcy、FIB、D-D、LDL-C最高,轻型组最低;重型组Ca^(2+)、TBIL、DBIL、IBIL最低,轻型组最高,3组以上指标的组间差异均有统计学意义(P<0.05)。病情轻重程度与血清UA、Hcy、FIB、D-D、LDL-C呈正相关关系(P<0.05),与血清Ca^(2+)、TBIL、DBIL、IBIL呈负相关关系(P<0.05)。恶化组患者UA、Hcy、LDL-C最高,好转组最低;恶化组TBIL、DBIL、IBIL最低,好转组最高,3组患者以上指标的组间差异均有统计学意义(P<0.05)。预后与血清UA、Hcy、LDL-C呈正相关关系(P<0.05),与血清TBIL、DBIL、IBIL呈负相关关系(P<0.05)。结论血清UA、Hcy、FIB、D-D、LDL-C、Ca^(2+)、TBIL、DBIL、IBIL与急性脑梗死患者病情轻重均明显相关,血清UA、Hcy、LDL-C、TBIL、DBIL、IBIL与预后之间也有明显相关性。
Objective To analyze the correlation between function of liver and kidney and blood lipid indexes and the prognosis of acute cerebral infarction.Methods 100 patients with acute cerebral infarction were selected.Serum levels of uric acid（UA）,serum creatinine（Scr）,serum triglyceride（TG）,total cholesterol（TC）,low density lipoprotein cholesterol（LDL-C）,high-density lipoprotein cholesterol（HDL-C）,and blood calcium（Ca^（2＋））.Fasting blood glucose（FPG）,fibrinogen（FIB）,D two polymer（D-D）,serum homocysteine（Hcy）,total bilirubin（TBIL）,direct bilirubin（DBIL）,and indirect bilirubin（IBIL）UA,Scr,TG,TC,LDL-C,HDL-C,Ca^（2＋）,FPG,FIB,D-D,Hcy,TBIL,DBIL and IBIL were measured in all the patients the next morning after admission.According to the CSS score,the patients were divided into mild group（0-15 points,35 cases）,medium group（16~30 pointsminutes,34 cases）,heavy group 3（31~45 pointsminutes,31 cases）.The NIHSS score difference betweenin the scores of the two patients at admission and three months after the onset of the disease was calculated.The patients were divided into the improved group（score difference0 points,58 cases）,no change group（score difference =0,36 cases）aAnd worsening group（score difference 0 point,6 cases）.The levels of serum UA,Scr,TG,TC,LDL-C,HDL-C,Ca^（2＋）,FPG,FIB,D-D,Hcy,TBIL,DBIL,IBILof different severity and different prognosis of patients were compared and the relevance were analyzed.Results The levels of UA,Hcy,FIB,DD and,LDL-C were the highest in the heavy group and the lowest in the light group.The levels of Ca^（2＋）,TBIL,DBIL and IBIL were the lowest in the heavy group,and the highest in the light group.The differences of above indexes between the three groups were statistically significant（P0.05）.There were positive correlations between the severity of the disease with serum levels of UA,Hcy,FIB,D-D and LDL-C（P0.05）,and a negatively correlations with serum levels of Ca^（2＋）,TBIL,DBIL and IB
作者
孙树敏
张力辉
罗晓晨
李冬梅
王颖玲
孟庆红
安平顺
SUN Shurnin;ZHANG Lihui;LUO Xiaochen;LI Dongmei;WANG Yingling;MENG Qinghong;AN Pingshun(Department of Neurology ,Port Hospital of Hebei Port Group Co. ,Ltd. ,Qinhuangdao , Hebei 066022, Chin)
出处
《国际检验医学杂志》
CAS
2018年第10期1215-1219,共5页
International Journal of Laboratory Medicine
基金
河北省秦皇岛市科技局(201502A213)
关键词
急性脑梗死
生化指标
预后
相关性
acute cerebral infarction
biochemical indexicators
prognosis
correlation
