摘要
目的对送检的疑似新生儿溶血病标本检测,查找患儿黄疸原因,为临床诊断治疗和输血提供实验室检测依据。方法血型血清学方法检测患儿及父母的ABO、Rh及其他系统血型;意外抗体筛查和鉴定试验检测产妇血清特异性抗体;库姆、释放、游离试验检测患儿由血型不合导致的溶血病。结果患儿检测出含有ABO血型系统的溶血病,产妇因有多次妊娠和输血史,其血清检出抗E和抗Fyb抗体,但患儿无这两个相应血型抗原,没有产生ABO血型系统以外的溶血病。患儿游离试验检出来自母体的抗E和抗Fyb抗体,因此输血需谨慎,除考虑ABO溶血病给予O型洗涤红细胞外,还要避开抗E和抗Fyb抗体选择相应抗原阴性的血液进行输注。结论新生儿溶血病是常见的新生儿科黄疸性疾病,其治疗关键在于及时,因此新生儿溶血病的实时诊断非常必要,除考虑ABO及Rh D溶血病外,在产妇有多次妊娠或输血史时更应注意ABO以外的血型系统引起的溶血病,这同时对指导新生患儿的临床输血至关重要。
Objective To detect the blood sample of hemolytic newborn and investigate the reason of jaundice, guiding clinical diagnosis and blood transfusion. Methods ABO, Rh and other blood types of the newborn and its parents were detected by serological method; Irregular antibody in the mother＇s blood serum was identified; Coombs, elution and liberation testwere determined to identify hemolytic disease of the newborn. Results ABO hemolytic disease of the newborn was identified with positive results. Due to times of transfusion and pregnancy, anti-E and Fyb were detected in the mother＇s blood serum. No other hemolytic disease but ABO was shown on the newborn, whose blood type was no E and Fyb antigens. The clinical transfusion for the newborn must be careful because of the anti-E and Fyb existing in the newborn＇s blood. The positive choice was O washed red blood cell with E and Fyb blood types. Conclusion Definite diagnosis of hemolytic disease of the newborn was necessary, providing evidence for clinical treatment and transfusion.
作者
种靖慧
吴丽娜
黄娴
李彤彤
CHONG Jinghui;WU Lina;HUANG Xian;LI Tongtong(Research Room of Immunohematology, Tianjin Blood Center, Tianjin 300110, China)
出处
《继续医学教育》
2018年第5期90-92,共3页
Continuing Medical Education
关键词
新生儿溶血病
ABO血型
血型抗体
临床输血
hemolytic disease of the newborn
blood group of ABO
antibody of blood group
clinical transfusion
