摘要
莱莉酸类物质作为植物体内源激素，能够诱导萜类、生物碱和黄酮类等多种药用活性成分在植物体内的生物合成，在植物次生代谢过程中发挥着非常重要作用。茉莉酸信号通路中的转录因子能通过与靶基因启动子中的顺式作用元件相互作用，激活或抑制植物次生代谢生物合成途径中多个关键酶基因的表达，有效地启动或关闭次生代谢生物合成途径，调控特定次生代谢产物的生物合成过程，从而影响次生代谢产物的积累。该文主要综述了莱莉酸信号通路中的转录因子（包括AP2／ERFs，bHLH，MYB，WRKY）在植物次生代谢中的调控作用等方面的研究进展，并探讨了转录因子在提高药用活性成分方面的潜在应用价值，为解析茉莉酸信号通路调控植物内的次生代谢过程提供参考和依据。
Jasmonates, as a plant endogenous hormone, can induce the biosynthesis of terpenoids, alkaloids and flavonoids and other medicinal active ingredients, and play an important role in the plant secondary metabolic process. The tanscription factors can ac- tivate the expression of multiple genes in the biosynthesis of plant secondary metabolites by binding the cis-elements of the target genes. Then, it effectively activates or inhibits the activities of the enzymes on the biosynthesis of plant secondary metabolites, further regulate specific biosynthesis and accumulation of secondary metabolites. Here, We review recent major progresses regarding the regulation of secondary metabolites by JAs-responsive transcription factors （TFs） （including AP2/ERFs, bHLH, MYB and WRKY）. That provides suggestions for further analysis of jasmonic acid signaling pathway and regulation of secondary metabolism, and explores the potential value of transcription factor in improving the medicinal active ingredients.
作者
姚娜
荆礼
郑汉
陈敏
申业
YAO Na1, JING Li1,2, ZHENG Han1,3, CHEN Min1 , SHEN Ye1(1. State Key Laboratory Breeding Base of Dao-di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China ; 2. Innovation Practice Center, Changchun University of Traditional Chinese Medicine, Changchun 130117, China; 3. College of Pharmacy, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, Chin)
出处
《中国中药杂志》
CAS
CSCD
北大核心
2018年第5期897-903,共7页
China Journal of Chinese Materia Medica
基金
中央级公益性科研院所基本科研业务费专项资金项目(ZZ0808018)
国家自然科学基金项目(81173490,81573533)
关键词
茉莉酸
茉莉酸信号通路
转录因子
次生代谢
jasmonic acid
JA signaling pathway
transcription factors
secondary metabolism
