摘要
目的探讨血清同型半胱氨酸(Hcy)和C-反应蛋白(CRP)联合检测在冠心病患者中的诊断价值。方法选自本院于2015年6月-2016年6月收治的冠心病患者81例作为研究对象,同时选自本院同期健康体检者72例。采用循环酶法测定Hcy,采用胶乳增强免疫比浊法(透射比浊法)测定CRP。比较2组血清Hcy和CRP水平变化及Hcy联合CRP特异度和灵敏度。结果观察组血清Hcy和CRP高于对照组(P<0.05);不稳定型心绞痛组和急性心肌梗死组血清Hcy和CRP含量高于稳定型心绞痛组,且急性心肌梗死组血清Hcy和CRP含量高于稳定型心绞痛组(P<0.05);Hcy联合CRP特异度和灵敏度均高于仅单项Hcy和CRP(P<0.05)。结论 Hcy和CRP与冠心病密切相关,联合检测有助于冠心病患者早期诊断。
Objective To investigate the diagnostic value of the combined detection of serum homocysteine(Hcy) and C-reactive protein(CRP) in patients with coronary heart disease(CHD). Methods Eighty-one patients with coronary heart disease who were admitted to our hospital from June 2015 to June 2016 were selected as the research objects,and 72 cases of healthy persons were selected from our hospital during the same period. Hcy was determined by cyclic enzymatic method and CRP was determined by Latex enhanced turbidimetric immunoassay. The levels of serum Hcy and CRP,and specificity and sensitivity of combined detection with Hcy and CRP between the two groups were compared. Results The serum levels of Hcy and CRP in the observation group were higher than that in the control group(P 〈 0. 05); serum Hcy and CRP levels in the unstable angina group and acute myocardial infarction group were higher than those in the stable angina group. Serum levels of Hcy and CRP were higher in the unstable angina group and acute myocardial infarction group than that in the stable angina group,and serum levels of Hcy and CRP in acute myocardial infarction group were higher than that in stable angina group(P 〈 0. 05); specificity and sensitivity of combined detection with Hcy and CRP was higher than that of single detection of Hcy or CRP(P 〈 0. 05).Conclusion Hcy and CRP are closely related to coronary heart disease,so combined detection is helpful for early diagnosis of coronary heart disease.
作者
李诺飞
LI Nuo - fei(School of Clinical Medicine, China Three Gorges University, Clinical Laboratory of Yichang Hospital of Traditional Chinese Medicine, Yichang, Hubei 443003, Chin)
出处
《中国卫生检验杂志》
CAS
2018年第9期1096-1098,共3页
Chinese Journal of Health Laboratory Technology
关键词
同型半胱氨酸
C-反应蛋白
冠心病
诊断价值
Homocysteine
C-reactive protein
Coronary heart disease
Diagnostic value