摘要
目的：探讨针刺结合活血方治疗不稳定型心绞痛的临床疗效及对血管内皮功能的影响。方法：选取2012年1月—2017年3月常州市第一人民医院心脏内科住院就诊的不稳定型心绞痛患者89例随机分为两组,对照组43例,观察组46例。对照组患者口服单硝酸异山梨酯片10 mg,3次/d;硫酸氢氯吡格雷片150 mg,1次/d;阿司匹林片100 mg,1次/d;西洛他唑片50 mg/次,2次/d;10 d为1个疗程,连续治疗3个疗程。观察组患者在对照组治疗的基础上,采用针刺心俞、巨阙、厥阴俞、膻中、内关、郄门、通里、阴郄等穴位结合中药当归、黄芪等活血方治疗,针刺治疗1次/d,中药1剂/d,分3次口服,均10 d为1疗程,连续治疗3个疗程。观察比较治疗前后两组患者血清TNF-α、NO及ET的含量、SV和EF水平、临床指标、血脂指标、血液流变学、肝肾功能指标以及临床疗效。结果：观察组患者血清TNF-α、NO及ET的水平均较对照组改善明显（P〈0.05）,观察组患者SV和EF水平也明显高于对照组（P〈0.05）;两组间肝肾功能指标无显著差异（P〉0.05）,TC及TG的水平则显著较对照组低（P〈0.05）;观察组患者心绞痛发作频率、持续时间、每周硝酸甘油用量均较对照组降低（P〈0.05）;总有效率观察组为91.3%,明显高于对照组的72.1%（P〈0.05）。结论：针刺结合活血方治疗不稳定型心绞痛疗效确切,明显优于单纯西药治疗,具体作用机制可能与改善血管内皮功能相关,值得临床推广应用。
Objective：To investigate the clinical effect of acupuncture combined with Huoxue Recipe on unstable angina pectoris and its influence on vascular endothelial function. Methods：Eighty-nine patients with unstable angina pectoris were randomly divided into 2 groups,43 cases in the control group and 46 cases in the observation group. The control group received Isosorbide Mononitrate Tablets（10 mg,3 times/d）,Clopidogrel Bisulfate Tablets（150 mg,1 time/d）,Aspirin Tablets（100 mg,1 time/d） and Cilostazol Tablets（50 mg,2 times/d）. Ten days was 1 course of treatment,continuously treating for 3 courses. Patients in the observation group based on the treatment in control group,were treated with acupuncture at Xinshu（BL15）,Juque（RN14）,Jueyinshu（BL14）,Danzhong（RN17）,Neiguan（PC6）,Ximen（PC4）,Tongli（HT5） and Yinxi（HT6） combined with angelica and Astragalus. The acupuncture treatment of traditional Chinese medicine was carried out once a day and the decoction 3 times a day. Ten days was for 1 course of treatment,continuously treating for 3 courses. The levels of serum TNF-α,NO and ET,SV and EF levels,clinical indexes,blood lipid indexes,blood rheology,liver and kidney function indexes and clinical efficacy were observed and compared between the two groups. Results：In the observation group,serum TNF-α,NO and ET levels were better than those of control group（P〈0. 05）. The observation group＇s SV and EF levels were significantly higher than those in control group（P〈0. 05）. There was no significant difference between the two groups＇ liver and kidney function indexes（P〈0. 05）. TC and TG levels of the control group were significantly lower（P〈0. 05）. The observation group＇s angina attack frequency,duration and weekly dosage of nitroglycerin were lower than those of the control group（P〈0. 05）. The total efficiency of the observation group was 91. 3%,significantly higher than the control group ＇s 72. 1%（P〈0. 05）. Conclusion：Acupuncture comb
作者
陆忠
孙舟红
LU Zhong, SUN Zhouhong(Department of Acupuncture and Moxibustion, Changzhou First People＇ s Hospital, Changzhou 213003, Jiangsu, Chin)
出处
《中华中医药学刊》
CAS
北大核心
2018年第5期1177-1180,共4页
Chinese Archives of Traditional Chinese Medicine
基金
江苏省卫生厅科技计划项目(H200647)
关键词
针刺
活血方
心绞痛
NO
SV
acupuncture
Huoxue Recipe
angina pectoris
NO
SV
