摘要
目的对唐山市区社区获得性肺炎(CAP)患儿病原体分布及其耐药性情况进行分析,为临床治疗提供依据。方法选择2015年6月至2016年9月在唐山市3所市区医院住院及门诊治疗的300例CAP患儿作为研究对象,对其临床资料、病原体检测结果及耐药性情况进行分析。结果 300例CAP患儿中269例病原体检测结果为阳性,占89.7%,其中单纯性细菌、病毒、支原体、衣原体感染患儿所占构成比分别为30.9%、21.2%、19.7%、1.1%,73例为混合感染,占27.1%。83例细菌感染患儿中,构成比居前4位的分别是肺炎链球菌、大肠埃希菌、肺炎克雷伯菌及金黄色葡萄球菌。药敏试验结果显示,肺炎链球菌、金黄色葡萄球菌对青霉素、红霉素具有较高的耐药性,但对万古霉素均能保持良好的敏感性。肺炎克雷伯菌、大肠埃希菌对青霉素类及第1、2代头孢菌素具有较高的耐药性,但对亚胺培南等碳青霉烯类抗菌药物仍保持良好的敏感性。结论唐山市区儿童CAP的致病因素主要为细菌感染,其次为病毒、支原体,细菌感染中以肺炎链球菌、大肠埃希菌、肺炎克雷伯菌及金黄色葡萄球菌4种为主。
Objective To analyze the pathogen distribution and drug resistance in children with community acquired pneumonia （CAP） in Tangshan city. Methods A total of 300 children with CAP were selected,which were treated in three Tangshan Urban hospital from June 2015 to September 2016,clinical data,pathogen and drug resistance were analyzed. Results In 300 CAP children,pathogens test results of 269 cases were positive,accounting for 89.7%,in which simple bacterial,viral,mycoplasma,chlamydia infection accounting for 30.9%,21.2%,19.7%,1.1% respectively,73 cases with mixed infection,accounting for 27.1%.The most common infection was bacterial infection amounting 83 cases,in which the top four bacteria were Streptococcus pneumoniae,Escherichia coli,Klebsiella pneumoniae and Staphylococcus aureus.Drug sensitivity test results showed Streptococcus pneumoniae,Staphylococcus aureus had high resistance to penicillin,erythromycin,but maintained good sensitivity to vancomycin.Klebsiella pneumoniae,Escherichia coli had high resistance to penicillins,the 1st and 2nd generation cephalosporins,but maintained good sensitivity to imipenem and other carbapenem antibiotics. Conclusion The pathogenic factors of CAP in children in Tangshan city mainly infected with bacteria,followed by virus and mycoplasma,Streptococcus pneumoniae,Escherichia coli,Klebsiella pneumoniae and Staphylococcus aureus were the main bacteria.
作者
李雅杰
张全新
李锋
范东宁
何桦
LI Yajie;ZHANG Quanxin;LI Feng;FAN Dongning;HE Hua(Department of Psychiatry,Xiehe Hospital of Tangshan City,Tangshan,Hebei 063000,China;Tangshan Vocational and Technical College,Tangshan,Hebei 063003,China;Department of Intenal Medicine,Xiehe Hospital of Tangshan City,Tangshan,Hebei 063000,China)
出处
《检验医学与临床》
CAS
2018年第9期1278-1280,共3页
Laboratory Medicine and Clinic
关键词
唐山市区
社区获得性肺炎
儿童
病原体
耐药性
Tangshan urban area
community acquired pneumonia
children
pathogens
drug resistance
