摘要
目的探讨在老年慢性充血性心力衰竭(CHF)的治疗中应用阿托伐他汀联合曲美他嗪对患者心功能、血清氨基末端脑钠肽前体(NT-pro BNP)和超敏C反应蛋白(hs-CRP)的影响。方法将120例老年CHF患者随机分为对照组和研究组,每组60例。对照组应用曲美他嗪治疗,研究组应用阿托伐他汀联合曲美他嗪治疗,对比两组的治疗效果。结果研究组的治疗有效率高于对照组(P<0.05);治疗后两组的的左心室舒张末期内径(LVEDD)、左心室收缩期末期内径(LVESD)、左心室射血分数(LVEF)、NT-pro BNP、hs-CRP水平均有明显差异(P<0.05)。结论在老年CHF的治疗中应用阿托伐他汀联合曲美他嗪的效果显著,可改善患者的心功能,降低NT-pro BNP和hs-CRP水平。
Objective To investigate the effect of atorvastatin combined with trimetazidine on cardiac function, serum NT pro-brain natriuretic peptide（NT-proBNP） and high-sensitivity C reactive protein（hs-CRP） in elderly patients with chronic congestive heart failure（CHF）. Methods A total of 120 elderly patients with CHF were randomly divided into control group and study group, with 60 cases in each group. The control group was treated with trimetazidine, while the study group was treated with atorvastatin combined with trimetazidine, and the therapeutic effects of the two groups were compared. Results The total effective rate of treatment in the study group was higher than that of the control group（P〈0.05）.After treatment, there were significant differences in left ventricular end diastolic diameter（LVEDD）, left ventricular end systolic diameter（LVESD）, left ventricular ejection fraction（LVEF）, NT-proBNP and hs-CRP levels between the two groups（P〈0.05）. Conclusion Atorvastatin combined with trimetazidine is effective in the treatment of elderly CHF, which can improve cardiac function, reduce NT-proBNP and hs-CRP levels.
作者
毛电波
MAO Dian-bo(Cardiology Department, the People＇s Hospital of Tongguan County, Weinan 714300, China)
出处
《临床医学研究与实践》
2018年第14期31-32,共2页
Clinical Research and Practice
