摘要
目的分析糖皮质激素治疗类风湿关节炎(RA)并发骨质疏松(OP)的临床效果。方法选取我院收治的RA患者120例为研究对象,对患者的病程、关节压痛指数、关节肿胀数、CRP、ESR、RF、HAQ评分、关节功能和糖皮质激素用药情况等临床资料进行回顾性分析。结果 120例RA患者中,女性占比高于男性;75例患者(62.5%)正在或曾经服用糖皮质激素中,服用时间≥3个月患者48例(64.0%),服用剂量≥5 mg/d患者43例(57.3%);免疫抑制剂治疗患者75例(62.5%)。56例(46.7%)OP组患者中,女性OP患者占比82.1%,绝经后女性患者占比69.6%。OP组患者年龄大于非OP组,病程长于非OP组,ESR水平和HAQ积分高于非OP组,Ca浓度低于非OP组(P<0.05);OP组与非OP组的服用糖皮质激素治疗、糖皮质激素治疗时间、糖皮质激素服用剂量、免疫抑制剂使用情况及关节功能分级比较,差异具有统计学意义(P<0.05)。结论临床应加强对RA并发OP的认识,以对该疾病进行合理预防并采取积极的治疗措施。
Objective To analyze the clinical effect of glucocorticoid in the treatment of osteoporosis caused by（rheumatoid arthritis, RA）. Methods A total of 120 RA patients admitted in our hospital were selected as the research objects.The clinical data of the patients such as course of disease, joint pain index, joint swelling, CRP, ESR, RF, HAQ score, joint function and glucocorticoid medication were retrospectively analyzed. Results In 120 RA patients, the proportion of women was higher than that of men. In 75 RA patients（62.5%） took corticosteroids, there were taking time for 3 months of 48 cases（64.0%）, and taking 5 mg/d of 43 cases（57.3%）. There were 75 cases（62.5%） received immunosuppressive agents. Fifty-six（46.7%） RA patients in the OP group, the proportion of women was 82.1%, and the proportion of menopausal women was69.6%. Compared with the RA patients, in the non-OP group, there were older age, longer course of disease, higher levels of ESR and HAQ score and lower Ca concentration in the OP group（P〈0.05）. There were significant differences in glucocorticoid therapy, duration of glucocorticoid therapy, dosage of glucocorticoid, use of immunosuppressant and joint function grade between OP group and non-OP group（P〈0.05）. Conclusion The clinical understanding of RA complicated with OP should be strengthened in order to prevent the disease reasonably and take active treatment measures.
作者
赵欣
ZHAO Xin(Xi＇an No.5 Hospial, Xi＇an 710082, China)
出处
《临床医学研究与实践》
2018年第14期17-18,共2页
Clinical Research and Practice
