摘要
目的:系统评价补肾化痰法治疗肾虚痰阻型多囊卵巢综合征的疗效及安全性。方法:计算机检索中国知网、万方数据库、维普数据库及中国生物医学文献数据库,以及CochraneLibrary与PUBMED等国外数据库,查找补肾化痰法治疗肾虚痰阻型多囊卵巢综合征的随机对照试验,检索时间限为各数据库建库至2017年10月2日。2位研究人员分别独立进行文献检索、筛选、质量评价和数据提取,通过Rev Man5.3软件进行Meta分析。结果:共纳入15个随机对照试验研究,总样本量为1042例。Meta分析结果显示,补肾化痰法治疗肾虚痰阻型多囊卵巢综合征的治疗组与对照组相比,临床疗效有效率[RR=1.36,95%CI(1.26,1.47),P<0.00001],中医证候疗效[RR=1.33,95%CI(1.19,1.48),P<0.00001],排卵率[RR=1.72,95%CI(1.22,2.44),P=0.002],卵巢体积[MD=-1.09,95%CI(-1.75,-0.44),P=0.001],BMI(体重指数)[MD=-0.83,95%CI(-1.19,-0.46),P<0.00001],BBT(基础体温)[RR=1.71,95%CI(1.43,2.05),P<0.00001],LH(促黄体生成素)水平[MD=-0.93,95%CI(-1.19,-0.68),P<0.00001],T(睾酮)值[MD=-0.83,95%CI(-1.19,-0.46),P<0.00001],其差异均具有统计学意义(P<0.05)。纳入研究有12项报道了不良反应情况,其余3项未加以报道。结论:补肾化痰法治疗肾虚痰阻型多囊卵巢综合征的疗效显著,与常规西药治疗相比具有一定优势,但由于本系统评价纳入的研究总体质量较低,研究数量较少,故仍需更多大样本、高质量的随机双盲对照试验加以验证。
Objective： To systematically evaluate the efficacy and safety of Bushen Huatan method method treating kidney-deficiency and phlegm-dampness type of polycystic ovary syndrome. Methods： All researches on the randomized controlled trials of it were retrieved and collected from Cochrane Library, PubMed, CNKI, WANFANG, VIP,CBM, each database retrieval time until Oct. 2, 2017. Two researchers respectively retrieved, screened, assessed quality and extracted data. Revman5.3 software was used to analyze. Results： 15 studies involving 1042 participants were included. The Meta analysis results showed that： The treatment group of it on the clinical efficiency compared with the controlled group [RR=1.36, 95%CI（1.26, 1.47）, P〈0.0001], the efficiency of TCM syndrome [RR=1.33, 95%CI（1.19,1.48）, P〈0.00001], the ovulation rate [RR=1.72, 95%CI（1.22, 2.44）, P=0.002], ovarian volume [MD=-1.09, 95%CI（-1.75,-0.44）, P=0.001], BMI [MD=-0.83, 95%CI（-1.19,-0.46）, P〈0.00001], BBT [RR=1.71, 95%CI（1.43, 2.05）,P〈0.00001], LH [MD=-0.93, 95%CI（-1.19,-0.68）, P〈0.00001], T [MD=-0.05, 95%CI（-0.07,-0.02）, P〈0.0001], the differences were statistically significant（P〈0.05）. There were 12 researches that reported untoward effect, the other didn＇t. Conclusion： Bushen Huatan method treating Kidney-deficiency and phlegm-dampness type of polycystic ovary syndrome has distinct advantages compared with conventional western medicine. But the included researches had low quality and a small quantity, so this study still need more large sample and high quality randomized controlled trials to verify.
作者
王艳辉
李涵
李新民
WANG Yanhui,LIHan,LI Xinmin(Henan University of Chinese Medicine, Henan Zhengzhou 450000, Chin)
出处
《中医药临床杂志》
2018年第4期690-697,共8页
Clinical Journal of Traditional Chinese Medicine
基金
河南中医药大学2017年度教育教学改革研究项目
项目编号:2017JX45
关键词
补肾化痰法
多囊卵巢综合征
肾虚痰阻型
随机对照试验
系统评价
Bushen Huatan method
Polycystic ovary syndrome
Kidney-deficiency and phlegm-dampness type
Randomized controlled trials
Systematic review
