摘要
目的:调查分析2型糖尿病(T2DM)患者中血糖达标对肾小管重吸收功能的影响。方法:收集149例住院T2DM患者和50例正常对照者的血液和尿液,测定糖化血红蛋白(HbA1c)、尿α1微球蛋白(α1-MG)、尿肌酐浓度,计算尿α1-微球蛋白尿肌酐比值(α1/CR)。根据HbA1c水平将糖尿病患者分为血糖达标(HbA1c<7%)和不达标(HbA1c≥7%)两组,分析两组间肾小管重吸收功能指标之间的差异。结果:2型糖尿病组的尿α1/CR水平显著高于对照组(P<0.001),其中血糖达标和不达标两组间的尿α1-MG(P=0.309)和α1/CR(P=0.838)不存在显著性差异。结论:在2型糖尿病患者中广泛存在肾小管重吸收功能损伤,控制血糖达标能否改善肾小管重吸收功能尚不明确,有待进一步研究。
Objective： To investigate the efteet of blood glucose level on renal tubular reabsorption function in patients with type 2 diabetes （T2DM）. Methods： A total of 149 hospital patients with T2DM and 50 nomlal controls were enrolled and the blood and urine samples were collected. The levels ofglyeosylated hemoglobin （HbAle）, urinary cd-mieroglobulin （α1-MG）, urinary ereatinine were decteeted, and the urine α1-microglobulin urine creatinine ratio （α1/CR） were calculated. Patients were divided into two groups according to the HbAlc levels： HbAlc 〈7% as standard group based on glycemic control standard and HbAlc ≥ 7% as the other group. The differences in renal tubular reabsorption function index between the two groups were statistically analyzed. Results： The level of urine α1/CR in T2DM group was significantly higher than that in control group （P 〈0.001）, and there was no significant difference in the levels of urinary α1-MG （P =0.309） and α1/CR （P =0.838） between the two groups. Conclusion： Renal tubular reabsorption injury is common in type 2 diabetes mellitus. Now it remains unclear whether glycemic control improves renal tubular reabsorption function, and further studies are needed.
作者
张茜
姜旭
刘蕊
崔小璠
曹玉洁
ZHANG Qian;JIANG Nu;LIU Rui;CUI Xiao-tan;CAO Yu-jie(Graduate School, Tianjin Medical University, Tianjin 300070, China;Department of Clinical Laboratory, Tianjin Union Medical Center, Tianjin 300121, China)
出处
《天津医科大学学报》
2018年第3期220-223,共4页
Journal of Tianjin Medical University
基金
天津市卫计委立项项目基金资助(2015KZ059)
关键词
2型糖尿病
糖化血红蛋白
尿Α1微球蛋白
尿α1-微球蛋白尿肌酐比值
type 2 diabetes mellitus
glycosylated hemoglobin
urine α1-microglobulin
urine α1-microglobulin urine creatinine ratio
