摘要
目的观察曲美他嗪联合雷米普利治疗老年缺血性心脏病合并心力衰竭的疗效及对心功能的影响。方法选取医院2014年3月至2017年3月收治的老年缺血性心脏病合并心力衰竭患者88例,根据随机数字表法分为观察组和对照组,各44例。两组均给予基础治疗,对照组在此基础上加服雷米普利,观察组左心室在对照组治疗基础上加用曲美他嗪,两组均连续治疗6个月。结果观察组总有效率为95.45%,显著高于对照组的81.82%(P<0.05);治疗后,观察组射血分数(LVEF)、心输出量(CO)、每搏输出量(SV)分别为(49.20±10.37)%,(5.97±0.95)L/min,(78.30±11.66)mL,显著高于对照组的(41.24±10.26)%,(5.34±0.84)L/min,(72.19±11.22)mL(P<0.05);观察组峰值速率比(A/E)、左室收缩末容积(LVESV)、左室舒张末容积(LVEDV)分别为0.73±0.27,(156.40±37.25)mL,(203.24±40.74)mL,显著低于对照组的0.88±0.35,(173.93±38.98)mL,(219.20±45.73)mL(P<0.05);治疗后,观察组血清总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)水平分别为(4.49±0.64)mmol/L,(1.72±0.58)mmol/L,(2.15±0.54)mmol/L,显著低于对照组的(5.15±0.68)mmol/L,(2.01±0.61)mmol/L,(2.51±0.67)mmol/L(P<0.05),高密度脂蛋白胆固醇(HDL-C)水平为(1.23±0.19)mmol/L,显著高于对照组的(1.14±0.16)mmol/L(P<0.05);观察组血浆超敏C反应蛋白(hs-CRP)水平为(2.48±0.22)mg/L,显著低于对照组的(3.52±0.33)mg/L(P<0.05)。结论曲美他嗪联合雷米普利治疗老年缺血性心脏病合并心力衰竭,可明显改善患者的心功能和延缓心室重塑进程,改善血脂代谢,降低hs-CRP水平,提高临床疗效。
Objective To observe the clinical effect of trimetazidine combined with ramipril in the treatment of elderly patients with ischemic heart disease complicated with heart failure and its effect on cardiac function. Methods Totally 88 patients with ischemic heart disease complicated with heart failure admitted to our hospital from March 2014 to March 2017 were selected and randomly divided into the observation group and the control group by the random number table method,44 cases in each group. All patients were given basic treatment,on the basis,the control group was treated with ramipril,while the observation group was treated with trimetazidine combined with ramipril. The two groups were continously treated for 6 months. Results The total effective rate of the observation group was 95. 45%,which was significantly higher than 81. 82% of the control group（ P 〈 0. 05）. After treatment,the left ventricular ejection fraction（ LVEF）,cardiac output（ CO） and stroke volume（ SV） in the observation group were（ 49. 20 ± 10. 37） %,（ 5. 97 ± 0. 95） L/min,（ 78. 30 ± 11. 66） m L,which were significantly higher than（ 41. 24 ± 10. 26） %,（ 5. 34 ± 0. 84） L/min,（ 72. 19 ± 11. 22） mL in the control group（ P 〈 0. 05）,while the ratio of peak velocity（ A/E）,left ventricular end systolic volume（ LVESV） and left ventricular end diastolic volume（ LVEDV） in the observation group were 0. 73 ± 0. 27,（ 156. 40 ± 37. 25） mL and（ 203. 24 ± 40. 74） mL,which were significantly lower than 0. 88 ± 0. 35,（ 172. 93 ± 38. 98） mL,（ 219. 20 ± 45. 73） mL in the control group（ P 〈 0. 05）. After treatment,the levels of serum total cholesterol（ TC）,triacylglycerol（ TG） and low-density lipoprotein cholesterol（ LDL-C） in the observation group were（ 4. 49 ± 0. 64） mmol/L,（ 1. 72 ± 0. 58） mmol/L,（ 2. 15 ± 0. 54） mmol/L,which were significantly lower than（ 5. 15 ± 0. 68） mmol/L,（ 2. 01 ± 0. 61） mmol/L,（ 2. 51 ± 0. 67） mmol/L in t
作者
彭玲
孙华
徐磊
罗迦
王建平
Peng Ling;Sun Hua;Xu Lei;Luo Jia;Wang Jianping(Department of Geriatrics, Guangyuan Central Hospital, Guangyuan, Sichuan, China 62800)
出处
《中国药业》
CAS
2018年第10期67-70,共4页
China Pharmaceuticals
关键词
曲美他嗪
雷米普利
缺血性心脏病
心力衰竭
老年
心功能
trimetazidine
ramipril
ischemic heart disease
heart failure
elderly
cardiac function
