摘要
目的通过分析雌激素受体(ER)基因型在绝经期腱鞘炎女性患者、绝经期健康女性和非绝经期健康女性的分布情况,研究ER基因与女性腱鞘炎发病的关联性。方法选取2012年8月至2015年12月中山大学附属第八医院门诊收治的绝经期女性111例,其中48例为腱鞘炎患者(A组),63例绝经期健康女性(B组);另选取63例非绝经期健康女性(C组)作为对照。采集三组研究对象早晨空腹外周静脉血,采用聚合酶链反应技术检测ER基因型分布,并进行相关性分析。结果 A组患者ER基因型分布及ER基因多态性与B、C组比较,差异均无统计学意义(P>0.05)。结论 ER基因多态性与绝经期女性腱鞘炎发病无明显关系。
Objective The relationship between the estrogen receptor（ER）gene and the incidence of tenosynovitiswas studied by analyzing the distribution of the ER genotypes in women with menopause tenosynovitis,menopause healthy wom-en and non menopause healthy women.Methods A total of 111 cases of menopause women in the Eighth Affiliated Hospital of Yat-sen Universtity were selected from August 2012 to December 2015,which 48 cases were tenosynovitis（group A）,63 casesmenopause healthy women（group B）,and 63 non menopause healthy women as control（group C）.Collected three groups ofsubjects in the morning,and the distribution of ER genotype was detected by polymerase chain reaction,and correlation analy-sis was performed.Results There were no significant differences in ER genotype distribution and ER gene polymorphism be-tween group A and group B and C（P〈0.05）.Conclusion ER genetic polymorphism in postmenopausal women has no obviousrelationship of tenosynovitis.
作者
黄爱军
汪曾荣
陈丽萍
马树强
陈瑞云
陆学东
林昆
黄醒中
陈庠仑
HUANG Aijun;WANG Zengrong;CHEN Liping;MA Shuqiang;CHEN Ruiyun;LU Xuedong;LIN Kun;HUANG Xing zhong;CHEN Xianglun(Department of Orthopaedics, the Eighth Affiliated Hospital of Yat-sen University （ Futian, Shenzhen ） Shenhen , Guangdong 518033, China;Department of Orthopaedics, the Second People＇s Hospital of Futian , Shenzhen , Guang dong 518049, China)
出处
《现代医药卫生》
2018年第9期1300-1303,共4页
Journal of Modern Medicine & Health
基金
深圳市科技研发资金知识创新计划基础研究项目(45574403-0)
关键词
受体
雌激素
绝经期
妇女
腱鞘炎
基因型
多态性
限制性片段长度
Receptors,estrogen
Menopause
Women
Tenosynovitis
Genotype
Polymorphism,restriction fragment length
