摘要
目的观察地西他滨联合CAG方案治疗38例老年急性髓性白血病(AML)的疗效。方法将2012年1月—2016年1月在商丘市第一人民医院就诊,且年龄≥60岁AML患者,按治疗方案分为观察组(地西他滨联合CAG方案,38例)与对照组(CAG方案,39例),对比两组临床疗效及不良反应发生率,并以电话或门诊随访方式统计生存情况。结果观察组完全缓解病例占36.84%,缓解率为63.16%,总反应率(ORR)为68.42%,较对照组的15.38%、38.46%、43.59%高;观察组血小板减少发生率为21.05%,亦高于对照组的5.13%,对比差异有统计学意义(P<0.05),且截止2017年7月30日,观察组存活率(52.6%)高于对照组(28.21%),对比差异有统计学意义(P<0.05);但两组感染、出血、呕吐、脱发等并发症发生率对比无统计学意义(P>0.05)。结论地西他滨联合CAG方案治疗老年AML疗效更佳,较单一使用CAG方案能使患者获取更大的生存获益。
Objective To observe the curative effect of decitabine combined with CAG regimen on 38 elderly patients with AML. Methods Totally 77 AML patients with age≥60 years old treated in our hospital from Jan. 2012 to Jan.2016 were taken as the research objects,and they were divided into the observation group（n = 38） and control group（n = 39） according to their treatment plans. The observation group was given decitabine combined with CAG regimen,while the control group was given only CAG regimen. The clinical curative effects and incidence rates of adverse reactions in the two groups were compared,and their survival situations was were assessed by telephone or outpatient follow-up. Results The complete remission rate,remission rate and ORR in the observation group were respectively36. 84%,63. 16% and 68. 42% which were higher than those in the control group 15. 38%,38. 46% and 43. 59%;The incidence rate of thrombocytopenia in the observation group was 21. 05% which was higher than that in the control group 5. 13%,their difference was statistically significant（P〈0. 05）,and at the end of July 30,2017,the survival rate of the observation group was（52. 6%） which was higher than that of the control group（28. 21%）,their difference was statistically significant（P〈0. 05）,but there was no significant difference in the incidence of complications such as infection,bleeding,vomiting and alopecia between the two groups（P〉0. 05）. Conclusion Compared with the single use of CAG regimen,decitabine combined with CAG regimen which has better curative effect for elderly patients with AML,can achieve greater survival benefits for patients.
作者
王根杰
田颖
WANG Gen- jie;TIAN Ying(The First People＇s Hospital of Shangqiu, Shangqiu Henan, 476100, China)
出处
《医药论坛杂志》
2018年第2期67-69,共3页
Journal of Medical Forum
