摘要
目的探讨血清性激素水平、体重指数与绝经后女性乳腺癌的发病的关系。方法选取我院2016年11月~2018年01月收治的绝经后女性乳腺癌患者63例进行研究,将其作为观察组,并选择同期进行治疗的绝经后乳腺良性病变患者57例,将其作为对照组,收集所有患者的临床资料,对比两组血清性激素水平、体重指数,并采用logistic回归分析血清性激素水平、体重指数与绝经后女性乳腺癌的发病的关系。结果观察组的睾酮(46.01±8.72)ng/d L、血清雌二醇(32.02±12.22)pg/m L显著高于对照组,差异具有统计学意义(P<0.05);观察组的孕酮、卵泡刺激素、黄体生成、催乳素水平、体重指数与对照组的相比,差异没有统计学意义(P>0.05);观察组中,超重患者的睾酮水平显著高于非超重患者的睾酮水平,差异具有统计学意义(P<0.05);排除其他影响因素,Logistic多因素回归分析发现绝经后女性乳腺癌的发病与睾酮、血清雌二醇水平有关(P<0.05)。结论睾酮、血清雌二醇水平与绝经后女性乳腺癌的发病相关,同时体重指数越高者,其睾酮水平越高。
Objective To investigate the relationship between serum sex hormone levels, body mass index （BMI） and the incidence of postmenopausal women with breast cancer. Methods In our hospital from November 2016 to 63 cases of breast cancer in 2018 01 months after menopause were studied as the observation group, and selected for treatment of postmenopausal patients with breast benign lesions in 57 cases, the control group, the clinical data of all patients were collected, compared two groups of serum sex hormone levels body mass index, and regression analysis of the relationship between the incidence of serum sex hormone levels, body mass index and postmenopausal women with breast cancer by logistic. Results The observation group of testosterone （46.01＋8.72） ng/dL, serum estradiol （32.02＋12.22） pg/mL was signi？cantly higher than the control group, the di？erence was statistically signi？cant （P〈0.05）; observation group of progesterone, follicle stimulating hormone, luteinizing hormone, prolactin compared with the control group, the level of body mass index, the di？erence was not statistically signi？cant. （P〉0.05）; in the observation group, overweight patients testosterone level was significantly higher than non overweight patients testosterone levels, the difference was statistically significant （P〈0.05）; the exclusion of other factors, Logistic regression analysis found that the incidence of postmenopausal women with breast cancer and testosterone, serum estradiol level （P〈0.05）. Conclusion The level of testosterone and serum estradiol is associated with the incidence of postmenopausal women with breast cancer, and the higher the body mass index, the higher the level of testosterone.
作者
黄若飞
HUANG Ruo-fei(Medical Laboratory Science 1,Red Cross Hospital of Wu zhou Guang xi 543002,China)
出处
《实用妇科内分泌电子杂志》
2018年第8期1-3,共3页
Electronic Journal of Practical Gynecological Endocrinology
关键词
绝经后女性
乳腺癌
血清性激素水平
体重指数
关系
Postmenopausal women
Breast cancer
Serum sex hormone levels
Body mass index
Relationship
