摘要
目的探讨血清Tiam1(T淋巴瘤诱导因子1)和Rac1(Ras3肉毒素底物1)蛋白在胃癌患者中的表达及影响因素。方法回顾性选取2016年3月至2017年3月自愿接受治疗的胃癌患者60例,根据病灶是否发生侵袭转移分为转移组(n=30例)和非转移组(n=30例)。对比两组患者血清Tiam1和Rac1蛋白表达情况,并分析其与肿瘤侵袭转移之间的关系。结果转移组患者的血清Tiam1和Rac1蛋白表达阳性率显著高于无转移组患者(P<0.05);转移组患者的血清Tiam1和Rac1 mRNA最大值以及中位数均显著高于无转移组患者;转移组患者的血清Tiam1和Rac1蛋白阳性表达存在显著相关性(P<0.05);Logistic分析结果显示,血清Tiam1和Rac1阳性表达是胃癌侵袭转移的重要风险因素(P<0.05)。结论血清Tiam1和Rac1在胃癌转移患者中呈高表达,能直接参与病灶的发生、发展,加强血清Tiam1和Rac1水平测定能评估患者预后,指导临床治疗。
Objective To analyze the clinical expressions and the influence factors of the Tiam1（ T-lymphoma invasion and metastasis inducing factor 1） and Rac1（ Ras-related C3 botulinum toxin substrate 1） proteins for patients with gastric carcinoma. Methods 60 patients with gastric carcinoma treated from March 2016 to March 2017 in our department were selected. The subjects were divided into metastasis group and non-metastasis group according to the tumor metastasis conditions,30 cases each group. The clinical expressions of the Tiam1 and Rac1 proteins and its correlation with the tumor invasion and metastasis were analyzed. Results The serum Tiam1 and Rac1 expressions for metastasis group were significantly higher than non-metastasis group（ P〈0. 05）. The minimum value,maximum value and median value of the serum Tiam1 and Rac1 mRNA expressions for metastasis group were significantly higher than non-metastasis group（ P〈0. 05）. For metastasis group,the positive rate of Tiam1 and Rac1 was positively correlated（ P〈0. 05）. According to the logistic regression analysis,it indicated that the risk factors of the tumor invasion and metastasis were the positive rate of the serum Tiam1 and Rac1 expressions（ P〈0. 05）. Conclusion The serum Tiam1 and Rac1 expressions are highly expressed in gastric carcinoma patients,which is directly involved into the genesis and development of the lesions. The detection of the serum Tiam1 and Rac1 expressions is helpful for the evaluation of the patient＇s clinical prognosis and treatment.
作者
彭微波
李幸子
PENG Wei - bo;LI Xing -zi.(Department of Pathology, The First Hospital Yichang , Yichang Hubei 443000, China)
出处
《临床和实验医学杂志》
2018年第9期937-940,共4页
Journal of Clinical and Experimental Medicine
