摘要
目的本课题通过调查中国人群(广东地区)冠心病(CHD)合并糖尿病(DM)、CHD合并糖耐量低减(IGT)人群血清脂联素(APN)、C反应蛋白(CRP)浓度水平,探讨APN、CRP在CHD患者2型糖尿病(T2DM)演进过程中的作用。方法采用横断面抽样调查对照研究,观察38例CHD伴糖耐量正常(NGT)患者、38例CHD伴IGT患者、44例CHD伴T2DM患者,进行空腹血糖(FPG)、APN和CRP的检测,并与对照组比较。结果 CHD患者(CHD伴NGT组、CHD伴IGT组、CHD伴T2DM组)血浆CRP水平高于对照组;CHD患者(CHD伴NGT组、CHD伴IGT组、CHD伴T2DM组)血浆APN水平低于对照组,差异均有统计学意义(P<0.05)。结论血浆APN在CHD合并T2DM的发生发展中发挥保护性作用,而CRP是损伤活动性的标志。
Objective To investigate the distribution of serum adiponectin （APN） and C-reactive protein （CRP） levels in Chinese population （Guangdong area） with diabetes mellitus （DM） and coronary heart disease （CHD） combined with CHD and impaired glucose tolerance （IGT）, and to explore the role of APN and CRP in the evolution of type 2 DM （T2DM） in CHD patients. Methods A cross-sectional sampling study was conducted in 38 patients with CHD but with normal glucose tolerance （NGT）, 38 cases with IGT and 44 cases with T2DM. Fasting plasma glucose （FPG）, APN and CRP were detected and compared with those in the control group. Results The CRP levels of patients with CHD （the group of CHD with NGT, the group of CHD with IGT, the group of CHD with T2DM） were higher than that of the control group. The APN levels of patients with CHD were lower than that of the control group. The differences were statistically significant （P〈0.05）. Conclusion APN plays a protective role in the development and progression of CHD combined with T2DM, and CRP is a marker of injury activity.
作者
肖斌欢
周颖玲
黎励文
唐崇工
XIAO Bin-huan;ZHOU Ying-ling;LI Li-wen;TANG Chong-gong(Department of Cardiology, the Third People＇s Hospital of Huizhou City, Huizhou Guangdong Province 516000, China;Institute of Cardiovascular Diseases in Guangdong General Hospital;the Third Affiliated Hospital of Guangdong Medical University （Maoming Petrochemical Industry Hospital of Guangdong Province)
出处
《中国城乡企业卫生》
2018年第4期111-112,共2页
Chinese Journal of Urban and Rural Enterprise Hygiene
关键词
糖尿病
脂联素
C反应蛋白
糖耐量试验
Diabetes mellitus
Adiponectin
C-reactive protein
Glucose tolerance test
