摘要
阿尔茨海默病（AD）受遗传机制、环境因素等多种因素影响，表观遗传学是连接遗传与环境因素的重要桥梁。DNA甲基化作为表观遗传学中的最重要的修饰，与衰老、癌症、痴呆等许多疾病有关。本文围绕近年来DNA甲基化在AD中的作用研究综述如下。
Prevalence of Alzheimer＇s disease, a neurodegenerative disease of the central nervous system, is increasing with the aging of population, causing serious social and family burdens. It is influenced by a variety of factors, including genetic and environmental ones. Epigenetics is an important bridge connecting genetic and environmental factors. DNA methylation, the most important modification in epigenetics, is related to many diseases like aging, cancer and dementia. In this paper, we reviewed the recent studies on the role of DNA methylation in AD.
作者
其勒木格
呼日勒特木尔
张春雨
Qilemuge;Huriletemuer;Zhang Chunyu(College of Postgraduates, Inner Mongolia Medical University, Huhhat 010050, China;Department of Neurology, Affiliated Hospital to Inner Mongolia Medical University, Huhhot 010050, China)
出处
《中华神经医学杂志》
CAS
CSCD
北大核心
2018年第4期424-427,共4页
Chinese Journal of Neuromedicine
基金
国家自然科学基金（81360177）
内蒙古自治区自然科基金[2015MS（LH）0813]
内蒙古自治区高等学校“青年科技英才支持计划”项目（NJYT-13-A08）.
