摘要
检索中国医院知识仓库、万方数据库、Pub Med等中英文数据库,收集各数据库自创建日期至2016年8月公开发表的关于棘球蚴病临床表现的文献。根据纳入排除标准筛选文献,使用Microsoft Office Excel2007建立数据库,利用R 3.2.3软件对纳入文献进行Meta分析,计算棘球蚴病分型、脏器出现率、严重程度分级及其构成和病死率。结果共纳入165篇文献,总计18 613例患者。细粒棘球蚴病患者和多房棘球蚴病患者分别占93.74%(17 447/18 613)、5.78%(1 076/18 613)。病灶出现率最高的脏器为肝(63.70%,11 857/18 613),其次为肺(24.13%,4 492/18 613)。棘球蚴病严重程度分为无症状、轻(中)症、重症,分别占6.17%(1 139/18 458)、66.12%(12 204/18 458)、27.71%(5 115/18 458),多房棘球蚴病的严重程度高于细粒棘球蚴病(χ2=164.560,P<0.05)。棘球蚴病术后1年病死率为0.83%(155/18 613),其中多房棘球蚴病术后1年病死率为2.27%(19/842),高于细粒棘球蚴病的0.70%(102/14 587)(χ~2=24.811,P<0.05)。提示棘球蚴病以肝为主要病灶器官,多房棘球蚴病的严重程度和病死率均高于细粒棘球蚴病。
By searching China Hospital Knowledge Database, WANGFANG DATA, and Pubmed, literature on clinical manifestations（signs/symptoms） of hydatidosis published from the foundation date of the databases to August,2016, was obtained. The publications were included in the meta-analysis according to the inclusion criteria. Meta-analysis was performed using Microsoft Office Excel 2007 and R 3.2.3 software to calculate the echinococcosis types, infection rate of organs, severity of the disease and mortality. A total of 165 papers were included in this study, adding up to 18 613 patients. The patients with cystic echinococcosis（CE） and alveolar echinococcosis（AE）constitute 93.74%（17 447/18 613） and 5.78%（1 076/18 613）, respectively. The lesions occurred more frequently in the liver（63.70%, 11 857/18 613）, followed by the lungs（24.13%, 4 492/18 613）. The disease severity was classified as asymptomatic（6.17%, 1 139/18 458）, mild and moderate（66.12%, 12 204/18 458）, and severe（27.71%, 5 115/18 458）. The severity of AE was higher than that of CE（ χ^2= 164.560, P〈0.05）. The one-year case fatality rate after surgery was 0.83%（155/18 613）. More specifically, the one-year case fatality rate of AE（2.27%, 19/842）after surgery was higher than that of CE（0.70%, 102/14 587）（ χ^2= 24.811, P〈0.05）. In conclusion, liver is the major involved organ in hydatidosis. The severity and mortality of AE are higher than those of CE.
作者
张梦媛
王立英
官亚宜
伍卫平
ZHANG Meng-yuan;WANG Li-ying;GUAN Ya-yi;WU Wei-ping(National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, WHO Collaborative Center for Tropical Diseases, National Center for International Research on Tropical Diseases, Ministry of Science and Technology, Key Laboratory of Parasite and Vector Biology, Ministryof Health, Shanghai 200025, Chin)
出处
《中国寄生虫学与寄生虫病杂志》
CAS
CSCD
北大核心
2018年第2期156-160,共5页
Chinese Journal of Parasitology and Parasitic Diseases
