摘要
目的:比较过敏性紫癜儿童血清25(OH)D水平在春夏秋冬四季变化特点,分析季节变化对过敏性紫癜的影响。方法:选取2015年4月至2016年11月在川北医学院附属医院儿科住院治疗的132例患儿,并选取同期来本院儿童保健门诊的146例健康儿童,测定其血清25(OH)D,按季节分组,比较四季血清25(OH)D水平。结果:(1)过敏性紫癜儿童血清25(OH)D水平为(16.42±7.95)ng/m L,显著低于健康对照组儿童(31.55±12.09)ng/m L(P<0.05);(2)维生素D受季节影响而波动,病例组和健康对照组冬春季的维生素D水平低于夏秋季。同季节的病例组与对照组血清25(OH)D比较,病例组均显著低于同季节的健康对照组。结论:过敏性紫癜儿童维生素D水平较低,维生素D水平受季节因素的影响可能参与了过敏性紫癜的发病。
Objective： To compare the Serum 25-hydroxy vitamin D levels in children with allergic purpura in four seasons,and to analysis the effect of the factor of season on allergic purpura. Methods： To select 132 cases with allergic purpura from department of pediatrics between April 2015 and November 2015,and 146 healthy children who were from children health clinic of the hospital in the same time. To determine the level of Serum 25-hydroxy vitamin D,grouped by season,and to compare serum 25（ OH） D level in the four seasons. Results： The level of serum 25（ OH） D of children with allergic purpura was significantly lower than healthy group（ 16. 42 ± 7. 95 ng/ml vs. 31. 55 ± 12. 09 ng/ml,P〈0. 05）. Vitamin D was affected by season. The level of serum 25（ OH） D in control group in winter and spring was significantly lower than in summer and autumn（ P〈0. 05）,as well as in case group. The level of serum25（ OH） D in the case group was significantly lower than the control group in the same season. Conclusion： The level of vitamin D is lower in children with allergic purpura. Seasonal factors may be involved in the pathogenesis of allergic purpura.
作者
杨洁
王建军
陈芳
周小敏
陈伽豪
吕晓江
秦莉
梁婷
YANG Jie;WANG Jian-jun;CHEN Fang;ZHOU Xiao-min;CHEN Jia-hao;LV Xiao-jiang;QIN Li;LIANG Ting(Department of Pediatrics,Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, Sichuan, Chin)
出处
《川北医学院学报》
CAS
2018年第2期181-183,201,共4页
Journal of North Sichuan Medical College
基金
四川省教育厅科研项目基金(13ZA0224)
