摘要
目的探讨依达拉奉联合前列地尔在急性脑梗死患者治疗过程中的临床疗效。方法 300例急性脑梗死患者随机分为观察组和对照组各150例,对照组接受丹参注射液和胞二磷胆碱注射液治疗,观察组接受依达拉奉和前列地尔治疗;观察患者治疗前和治疗后的神经功能缺损评分(NDS)和日常生活能力评分(ADL),观察患者治疗后的临床总有效率、并发症发生情况。结果治疗后,观察组NDS评分低于对照组,ADL评分高于对照组,差异有统计学意义(P<0.05);观察组临床总有效率高于对照组,总并发症发生率低于对照组,差异有统计学意义(P<0.05)。结论依达拉奉联合前列地尔治疗急性脑梗死患者,可以有效降低神经功能缺损,改善日常生活能力,临床疗效优于丹参注射液和胞二磷胆碱注射液治疗。
Objective To evaluate the clinical efficacy of edaravone combined with alprostadil in the treatment of acute cerebral infarction.Methods 300 patients with acute cerebral infarction were randomly divided into an observation group（ n= 150） and a control group（ n = 150）. The control group was treated with Danshen injection and Citicoline injection while the observation group was treated with edaravone and alprostadil. The neurological deficit scores（ NDS） and activities of daily living（ ADL） before and after treatment were observed,and the total clinical effective rate and complications were observed. Results After treatment,the NDS score in the observation group was lower than that in the control group（ P〈0.05）; the ADL score in the observation group was higher than that in the control group（ P〈 0. 05）. The total clinical efficiency of the patients in the observation group was higher than that in the control group（ P〈0.05）; the incidence of total complications in the observation group was lower than in the control group（ P〈 0. 05）. Conclusions Edaravone combined with alprostadil in the treatment of patients with acute cerebral infarction can effectively reduce neurological deficit and improve daily living ability,and the clinical efficacy is better than that of Danshen injection and Citicoline injection.
作者
王志
徐汉文
杨建邦
WANG Zhi;XU Han-wen;YANG Jian-bang(Department of Neurology;Department of Geriatrics, Guangfu Hospital of Zhejiang Jinhua Jinhua 321000, China)
出处
《健康研究》
CAS
2018年第2期196-198,共3页
Health Research
关键词
依达拉奉
前列地尔
急性脑梗死
临床疗效
edaravone
alprostadil
acute cerebral infarction
clinical efficacy
