摘要
目的分析莫沙必利联合奥美拉唑对老年功能性消化不良患者胃肠激素与胃肠动力的影响。方法选择中国人民解放军第二五四医院在2015年5月至2017年5月期间收治的96例老年功能性消化不良患者,按抽签法随机分为对照组和研究组,每组各48例。对照组给予莫沙必利治疗,研究组在此基础上,联合奥美拉唑治疗。比较两组患者的临床疗效、胃动素(MTL)、促胃泌素(GAS)、血管活性肽(VIP)、生长抑素(SS)、胆囊收缩素(CCK)、小肠推进率、胃排空率和不良反应。结果研究组总有效率明显高于对照组,差异具有统计学意义(P<0.05)。治疗后,两组MTL、GAS、小肠推进率、胃排空率均较治疗前上升,且研究组明显高于对照组,差异具有统计学意义(P<0.05);两组VIP、SS、CCK均较治疗前下降,且研究组明显低于对照组,差异具有统计学意义(P<0.05)。两组不良反应比较差异无统计学意义(P>0.05)。结论莫沙必利联合奥美拉唑对老年功能性消化不良患者的临床疗效优于单用莫沙必利,其可调节胃肠激素分泌,改善胃肠动力,且不会增加药物的不良反应,值得临床推广应用。
Objective This paper attempts to analyze effects of mosapride and omeprazole on gastrointestinal hormones and gastrointestinal dynamics in elderly patients with functional dyspepsia.Methods Ninety six cases of elderly functional dyspepsia from May 2015 to May 2017 in No.254 Hospital,the Chinese People′s Liberation Army were selected and randomly divided into the control group and the research group,48 cases in each group using the lottery method.The control group was treated with mosapride,while the research group was treated with omeprazole aside from mosapride.The clinical curative effect,motilin（MTL）,promote gastric gastrin-releasing（GAS）,vascular active peptide（VIP）,somatostatin（SS）,cholecystokinin（CCK）,small intestine propulsion rate,gastric emptying rate,and adverse reactions of the two groups were compared.Results The total effective rate of the research group was significantly higher than that of the control group,and the difference was statistically significant（P〈0.05）.After treatment,the MTL,GAS,small intestine propulsion,and the gastric emptying rate of the two groups were raised than those before treatment,of which the research group were significantly higher than the control group,and the difference was statistically significant（P〈0.05）.The VIP,SS,and CCK of the two groups were decreased than those before treatment,of which the research group were obviously lower than the control group,and the difference was statistically significant（P〈0.05）.The adverse reaction rate of the two group was no difference（P〈0.05）.Conclusions The clinical effects of mosapride and omeprazole on treatment of elderly functional dyspepsia patients is better than mosapride alone.It can regulate the secretion of gastrointestinal hormones,improve the gastrointestinal dynamics,and without increasing adverse drug reactions,which is worthy of clinical application.
作者
郭华
张靖
田静
邱荣
段翔
郑伟
GUO Hua;ZHANG Jing;TIAN Jing;QIU Rong;DUAN Xiang;ZHENG Wei(Department of Geriatrics,No.254 Hospital,the Chinese People′s Liberation Army,Tianjin（300142）,China)
出处
《国际消化病杂志》
CAS
2018年第2期121-125,共5页
International Journal of Digestive Diseases
关键词
老年功能性消化不良
莫沙必利
奥美拉唑
胃肠激素
胃肠动力
Elderly functional dyspepsia
Mosapride
Omeprazole
Gastrointestinal hormones
Gastrointestinal dynamics
