摘要
CD20是一种人白细胞分化抗原,表达于除浆细胞外的发育分化各阶段的B细胞表面,被公认为是B细胞的表面标志。最近研究发现,除了B细胞,在机体中存在一群CD3^+T细胞也表达CD20分子,这群细胞与传统的CD3^+T细胞有着相似而又独特的生物学特征,并在风湿性关节炎、多发性硬化及卵巢癌等多个疾病中发挥重要作用。因此,本文就该细胞亚群的最新研究进展作一综述。
CD20 is an activated-glycosylated phosphoprotein expressed on the surface of all B cells beginning at the pro-B phase and progressively increasing in concentration until maturity, and it is putative as a B-cell marker for its lack of expression on other cell lineages. However, recent studies have showed that a subset of CD3~＋T cells expressing CD20 has been identified, and this CD3~＋CD20~＋T-cell subset not only displays a similar and unique biological characteristic to classical CD3~＋T cells, but also plays an important role in many diseases such as rheumatoid arthritis, multiple sclerosis and ovarian cancer. Here, we provide an overview of the current knowledge about the phenotype and functional features of CD3~＋CD20~＋T cells as well as their roles in different diseases.
作者
周灏涵
袁顺翎
陈沁
朱宝行
刁玮博
彭六生
ZHOU Haohan;YUAN Shunling;CHEN Qin;ZHU Baohang;DIAO Weibo;PENG Liusheng(National Engineering Research Center of Immunological Products, Department of Microbiology and Biochemical Pharmacy, College of Pharmacy, Army Medical University, Chongqing 400038, China;The Battalion 18, College of Pharmacy, Army Medical University, Chongqing 400038, China;East China Military Material Purchasing Bureau, Shanghai 200433, China;Department of Dermatology, Southwest Hospital, Army Medical University, Chongqing 400038, China)
出处
《免疫学杂志》
CAS
CSCD
北大核心
2018年第5期456-460,共5页
Immunological Journal
