摘要
随着现代科学技术的进步和日益提高的生物化学知识水平,营养学在日常生活以及医疗中的作用开始逐步显现。利用营养学相关知识补充或者甚至用病理学条件下的饮食控制替代药物来治疗疾病已经得以实现。此外,使用营养作为辅助治疗方法以协同的方式增强药物效应,降低可能产生的不良反应和依赖性在众多领域中也得到了广泛证实。伴随肿瘤细胞代谢特点的研究深入,有实验表明,肿瘤细胞共有的最重要的特征是无论在有氧还是无氧条件下均主要使用葡萄糖(Warburg效应)进行供能。正是由于这种特殊的代谢方式,饮食控制被认为是肿瘤治疗中的重要策略。生酮饮食是一种高脂肪、低蛋白质和极低碳水化合物饮食方法,这种饮食的治疗机制可能潜在地影响肿瘤治疗和预后。生酮饮食治疗作为非药物治疗的重要组成部分,在国内外已系统广泛应用于小儿难治性癫痫治疗中,并取得显著成效。虽然生酮饮食在肿瘤动物模型实验上取得不错的效果,但临床实验研究却鲜有报道。因此,本文从生酮饮食在肿瘤治疗中的作用机制、临床应用效果方面综述了生酮饮食对于肿瘤患者的影响,为肿瘤非药物治疗研究提供借鉴。
With the advancement of modern science and technology and the increasing knowledge of biochemistry, the role of nutrition in daily life and medical treatment is gradually emerging. The use of nutritionally relevant knowledge to supplement or even treat diseases with diet-controlled alternative drugs under pathological conditions has been achieved. In addition, the use of nutrition as an adjuvant therapy in a synergistic manner to enhance the drug effect and to reduce the possible side effects and dependence has also been widely confrmed in many felds. With the tumor cell metabolism in-depth study, a research shows that the most important feature shared by tumor cells is that they are mainly energized with glucose （Warburg effect） both aerobically and anaerobically. It is because of this special metabolic approach that dietary control is considered as an important strategy in cancer therapy. The ketogenic diet is a high-fat, low-protein, and very low-carbohydrate diet that can potentially affect the treatment and prognosis of the tumor. As an important part of non-drug therapy, ketogenic diet therapy has been systematically applied in pediatric refractory epilepsy treatment both at home and abroad, and has achieved remarkable results. However, the application of ketogenic diet has rarely been reported in cancer treatment. Therefore, this article reviews the mechanism of action of ketogenic diet in cancer therapy and the effect of clinical application on cancer patients, and provides references for the study of non-drug treatment of cancer.
作者
张旭
孙迪
姜桂春
ZHANG Xu;SUN Di;JIANG Gui-chun(Liaoning University of Traditional Chinese Medicine, Shenyang 110042, Liaoning, China;Cancer Hospital of China Medical University, Liaoning Cancer Hospital, Shenyang 110032, Liaoning, China)
出处
《肿瘤代谢与营养电子杂志》
2018年第1期92-96,共5页
Electronic Journal of Metabolism and Nutrition of Cancer
关键词
生酮饮食
肿瘤
综述
Ketogenic diet
Neoplasm
Review
