摘要
目的分析早孕期联合检测PP13(胎盘蛋白13)、PAPP-A(妊娠相关血浆蛋白A)、Ut A-PI(彩色多普勒子宫动脉搏动指数)和3D-PDU胎盘血流参数对子痫前期(PE)的预防效果。方法选取在早孕期进行唐氏血清筛查和NT超声检查并计划在本院分娩的60孕妇作为研究组(轻度PE、重度PE各30例),另选取60例早孕期健康孕妇作为对照组,检测研究对象血清PP13和PAPP-A浓度,彩色多普勒测量Ut A-PI和三维能量多普勒测量胎盘血流参数,对数据进行统计分析。结果研究组血清PP13、PAPP-A浓度、Ut A-PI均较对照组低,差异有统计学意义(P<0.05)。研究组3D-PDU胎盘血流参数VI、FI、VFI均较对照组低,差异有统计学意义(P<0.05)。Logistic回归分析结果显示,PP13、PAPP-A表达异常以及Ut A-PI、3D-PDU胎盘血流参数异常改变均与PE的发生存在相关性(P<0.05)。结论早孕期检测PP13、PAPP-A、Ut A-PI和3D-PDU胎盘血流参数,可用于评估孕妇发生PE的风险,指导PE预防方案的制定。
Objective To analyze the preventive effect of combined detection of PP13（placental protein 13）,PAPP-A（pregnancy-associated plasma protein A）,Ut A-PI（color Doppler uterine artery pulsation index） and 3 D-PDU placental blood flow parameters on preeclampsia（PE） in early pregnancy. Methods Sixty pregnant women who underwent down＇s serum screening and NT ultrasound during early pregnancy and planned to give birth in our hospital were selected as the study group（30 cases of mild PE and 30 cases of severe PE）.Another 60 healthy pregnant women during early pregnancy were selected as the control group.The concentration of serum PP13 and PAPP-A in the study subjects was measured.Color Doppler measured of Ut A-PI and three-dimensional energy Doppler measured placental blood flow parameters,and the data were analyzed statistically. Results The serum levels of PP13, PAPP-A and Ut A-PI in the study group were lower than those in the control group（P 0.05）.The 3 D-PDU placental blood flow parameters VI,FI and VFI in the study group were lower than those in the control group,and the difference was statistically significant（P 0.05）.Logistic regression analysis showed that abnormal PP13,PAPP-A expression and abnormal changes of Ut A-PI,3 D-PDU placental blood flow parameters were correlated with PE（P0.05）. Conclusion Detection of PP13,PAPP-A,Ut A-PI and 3 D-PDU placental blood flow parameters in the early pregnancy can be used to assess the risk of PE in pregnant women and guide the development of PE prevention programs.
作者
吴素林
WU Sulin(Department of Obstetrics and Gyneeology,Zhongshan Hospital of Traditional Chinese Medieine,Guangdong Provinee,Zhongshan 528400,Chin)
出处
《中国医药科学》
2018年第8期70-72,共3页
China Medicine And Pharmacy
