摘要
本实验动态地检测了油酸所致大鼠肺血管通透性增高的发生、发展过程中肺组织中α、β肾上腺素能受体(αAR、βAR)的最大结合容量及亲和力的变化。结果发现:实验组大鼠肺组织中αAR与βAR之间的平衡遭到了破坏,αAR显著增多,而βAR却显著减少。应用αAR阻断剂——酚妥拉明或βAR激动剂——舒喘灵均可有效地防治油酸引起的大鼠肺血管通透性增高,使肺系数明显减小,支气管肺泡灌洗液中蛋白质含量明显减少,肺组织病变明显减轻。实验结果提示:肾上腺素能受体在肺微血管通透性的调控过程中可能起着重要的作用;肺组织中αAR与βAR之间的平衡失调可能是肺血管通透性增高的重要原因;纠正这种失衡是防治通透性肺水肿的有效手段。
The changes of maximal binding capacity (Bmax) of α- and β-adrenoceptors(αAR, βAR) in rat lungs during the pathogenesis of hyperpermeability of pulmonary microvasculature induced by oleic acid were characterized. After intravenous injection of oleic acid, an imbalance between αAR and βAR in the lungs was revealed. The Bmax of αAR increased significantly, while βAR decreased significantly. When animals were treated with phentolamine, an antagonist of aAR, or sultanole, an agonist of βAR, before or after the injection of oleic acid, the permeability pulmonary edema induced by oleic acid could be alleviated greatly. The lung coefficient and the protein concentration in bronchoalveolar lavage fluid decreased significantly and the histological changes were greatly improved. The results indicated that the adrenoceptors may play an important role in regulating the permeability of pulmonary microvasculature and the imbalance between αAR and βAR in the lung might be responsible for the hyperpermeability of pulmonary microvasculature. It is therefore considered that to restore the normal balance might be an important principle for preventing and treating the permeability pulmonary edema.
出处
《中国应用生理学杂志》
CAS
CSCD
1991年第4期311-315,共5页
Chinese Journal of Applied Physiology
基金
国家自然科学基金
军事医学科学院科学基金
关键词
肺水肿
肺血管
肾上腺素能
受体
adrenoceptor
pulmonary vasculature
oleic acid
