摘要
目的:观察院内制剂亚甲康胶囊对亚急性甲状腺炎急性期(热毒壅盛型)患者的治疗作用及对氧化应激状态的影响。方法:将符合纳入标准的68例患者采用随机数字表法分为2组各34例,治疗组予亚甲康胶囊治疗,对照组予强的松治疗。2组均治疗2月,于治疗前后检测生化指标,统计中医证候积分。结果:2组均能有效降低亚急性甲状腺炎患者中医证候积分,降低血白细胞(WBC)和血沉(ESR),改善甲状腺功能促甲状腺激素(TSH)、三碘甲腺原氨酸(T_3)、甲状腺素(T_4),差异均有统计学意义(P<0.01,P<0.05);且治疗组优于对照组,差异均有统计学意义(P<0.05);2组均能够降低氧化指标丙二醛(MDA),升高抗氧化指标超氧化物歧化酶(SOD),差异均有统计学意义(P<0.01,P<0.05),且治疗组优于对照组(P<0.05)。结论:亚甲康胶囊治疗亚急性甲状腺炎急性期(热毒壅盛型)疗效确切,其作用机制可能是降低了患者氧化应激水平,提高了机体抗氧化应激能力。
Objective：To observe the therapeutic effects of the nosocomial preparation namely Yajiakang capsules treating patients with subacute thyroiditis in acute stage（heat-toxin congestion and excessiveness type） and its influence on oxidative stress status. Methods：Divided 68 cases of patients in accordance with the inclusion criteria into two groups randomly,34 cases in each group. The treatment group was given Yajiakang capsules for treatment,while the control group was given prednisone for treatment. Both groups were treated for 2 months, detected the biochemical indexes before and after treatment,and statistically analyzed Chinese medicine syndrome scores. Results：Both groups could effectively decrease Chinese medicine syndrome scores,reduced white blood cells（WBC） and erythrocyte sedimentation rate（ESR）,and improved thyroid function,thyroid stimulating hormone（TSH）,triiodothyronine（T3） and thyroxine（T4） of patients with subacute thyroiditis,differences being significant（P〈0.01,P〈0.05）;and the treatment groups was better than the control group,difference being significant（P〈0.05）. Both groups could decrease the oxidation index malondialdehyde（MDA）, and increase the anti-oxidation index superoxile dismutase（SOD）,differences being significant（P〈0.01,P〈0.05）,and the treatment groups was better than the control group（P〈0.05）. Conclusion：Yajiakang capsules has definite clinical effect in treating subacute thyroiditis in acute stage（heat-toxin congestion and excessiveness type）,and its functional mechanism may be reducing the oxidative stress levels of patients and enhancing the anti-oxidative stress function of body.
作者
连琯
史晓伟
裴文丽
刘怡
谢卓霖
樊鹏翔
马如龙
张定华
LIAN Guan;SHI Xiaowei;PEI Wenli;LIU Yi;XIE Zhuolin;FAN Pengxiang;MA Rulong;ZHANG Dinghua
出处
《新中医》
CAS
2018年第3期91-95,共5页
New Chinese Medicine
基金
甘肃省中医药管理局科研立项课题(GZK-2016-37)
