摘要
目的观察右美托咪定复合七氟醚在小儿先天性心脏病(CHD)介入封堵术中的临床效果。方法采用随机数字表法将本院择期行CHD介入封堵术患儿60例分为观察组和对照组,每组30例。2组均采用喉罩下七氟醚吸入麻醉。观察组在吸入七氟醚的同时以0.4μg·kg^(-1)的右美托咪定持续泵注30 min,对照组以同样的方式持续泵注生理盐水。记录患儿入室时(T_1)、喉罩置入后(T_2)、穿刺即刻(T_3)、置封堵器即刻(T_4)和手术结束时(T_5)的平均动脉压(MAP)和心率(HR)。比较2组患儿的苏醒时间、镇静评分、躁动评分。结果在各时间点MAP和HR相比差异无统计学意义(P>0.05),2组苏醒时间及镇静评分方面无明显差异,观察组与对照组相比较躁动评分更低,差异有统计学意义(P<0.05)。结论右美托咪定复合七氟醚在小儿CHD介入封堵术中可减少躁动的发生,同时不影响患儿循环功能和苏醒时间。
AIM To observe the clinical effect of dexmedetomidine combined with sevoflurane in interventional procedures of congenital heart disease （CHD） in children. METHODS Totally 60 children with CHD un- dergoing interventionl therapy were randomly divided into observation group （group D, n = 30 ） and control group （group S,n =30）. induction, and the The 2 groups were treated by sevoflurane inhalation anesthesia under the laryngeal maskduring group D was administered at an initial loading dose（0.4 μg·kg^-1 for 30 rain） , and the group S was continuously injected with physiological saline in the same way. The mean arterial pressure （MAP） and heart rate （HR） were recorded after admission （T1）, after laryngeal mask inserted （T3）, immediate skin incision （T3） , immediate closure of occluder （T4 ） and end tation score were compared between the 2 groups. of surgery （T5）. The awakening time, Ramsay score and agi- RESULTS The MAP and HR had no statistically significant difference between the 2 groups （P 〉 0.05 ）. The awakening time and Ramsay score had no significant difference between the 2 groups. The Agitation score was lower in the group D compared with the group S （ P 〈 0.05 ）. CONCLUSION Dexmedetomidine combined with sevoflurane can reduce the occurrence of restlessness in interventional therapy for CHD in children, without affecting the circulatory function and recovery time.
作者
廖俊锋
彭文勇
LIAO Junfeng;PENG Wenyong(Department of Anesthesiology, Jinhua Central Hospital, Jinhua Hospital of Zhejiang University, Jinhua 321000 ,China)
出处
《中国临床药学杂志》
CAS
2018年第2期106-109,共4页
Chinese Journal of Clinical Pharmacy
基金
浙江省医学会计划项目(编号2012ZYC-A82)
关键词
先天性心脏病
介入治疗
七氟醚
右美托眯定
congenital heart disease
interventional therapy
sevoflurane
dexmedetomidine
