摘要
目的:观察改良FolFox4方案结合中医时间医学择时服药理论对晚期大肠癌患者生存质量及血清CEA的影响。方法:60例晚期大肠癌患者,随机分为治疗组和对照组(两组各30例)。治疗组:改良FolFox4方案:奥沙利铂50mg/m^2,持续静脉滴入3小时以上,d1;亚叶酸钙200mg/m^2,持续静脉滴入2小时,d1~d2;氟尿嘧啶(5-Fu)400mg/m^2,静脉推注,d1~d2,后续以600mg/m^2持续静脉滴入22小时,d1~d2;每两周重复。根据中医时间医学择时服药理论,从化疗第1天开始,于上午9~11点期间服用中药济川健脾固本方,每日1剂,每天1次。对照组:单纯采用改良Fol Fox4方案。治疗2个周期后,比较两组对患者生存质量及血清CEA的影响。生存质量评价采用EORTCQLQ-C30V3.0问卷式量表。结果:生存质量方面:治疗组在"疲倦"、"恶心与呕吐"方面优于对照组(P均<0.05)。治疗后总得分,治疗组和对照组分别为(63.33±10.63)和(54.17±16.05)分,t=2.609,P=0.012,差异有明显统计学意义。两组治疗前后血清CEA值的比较,及治疗后组间比较,经t检验,差异均无统计学意义(P均>0.05)。结论:改良Fol Fox4方案结合中医时间医学择时服药理论对晚期大肠癌患者生存质量有较好的改善,值得临床进一步研究。
Objective： To observe the quality of life（ QOL） and serum CEA effect of improved FOLFOX4 combined with the theory of medicine selection in time of TCM for treatment of patients with advanced colorectal cancer. Methods： 60 patients were randomly divided into controlled group and observation group,30 cases in each group. The controlled group： oxaliplatin was administered intravenously on d1 with 50 mg/m^2,leucovorin was given intravenously on d1 and d2 with 200 mg/m^2,5-FU was intravenous injection on d1 and d2 with 400 mg/m^2,and was administered intravenously 22 hours on d1 and d2 with 600 mg/m^2. Fortnightly interval repeat. According to the theory of medicine selection in time of TCM,from the first day of chemotherapy,took Chinese medicine Jichuan Jianpi Gunben Decoction at 9 to 11 am,one dose per day,one time a day,the observation group： Only with improved FOLFOX4. After two cycles,compared the effect of two groups on the QOL and serum CEA. The assessment methods of QOL was EORTCQLQ-C30 V3. 0 questionnaire. Results： On the QOL： The controlled group was improved more obviously in defecation,nausea and vomiting,the P values were all less than 0. 05. In total health score,the controlled group（ 63. 33±10. 63） and the observation group（ 54. 17±16. 05）,t= 2. 609,P = 0. 012,showed significantly better results than before chemotherapy. The two groups were compared to the serum CEA before and after treatment,and comparison between groups,after t test,the P values were all more than 0. 05. Conclusion： Improved FOLFOX4 combined with the theory of medicine selection in time of TCM for treatment of patients with advanced colorectal cancer has better improvement in the QOL,it is worthy of clinical for further investigation.
作者
陈琴
杨向东
CHEN Qin;YANG Xiang- dong(Chengdu Anorectal Hospital Chengdu Sichuan 610015, China)
出处
《四川中医》
2018年第3期85-89,共5页
Journal of Sichuan of Traditional Chinese Medicine
基金
成都市卫计委医学科研课题(编号:2015022)
关键词
晚期大肠癌
改良FolFox4
中医时间医学择时服药理论
济川健脾固本方
生存质量
Improved FOLFOX4
Medicine selection in time of TCM
Jichuan Jianpi Gunben Decoction
Advanced colorectal cancer
Quality of life （QOL）
Serum CEA
