摘要
目的:合成一类新型的抗肿瘤活性化合物,以期获得更高效,低毒,靶向性好的抗肿瘤先导药物。方法:通过先合成两类合适的卟啉分子,再通过不同长度的碳链桥利用分子间成醚键的方法将之与白杨素分子有机地结合,从而形成一类新型的卟啉-白杨素复合物。通过核磁共振氢谱,紫外-可见光谱确证化合物结构。然后利用标准的MTT方法检测化合物体外抗乳腺癌MCF-7细胞的活性。结果:成功合成了4个新型卟啉-白杨素复合物;利用MTT法检测其具有优于母体化合物的抗肿瘤活性。结论:本课题合成了一类具有深入研究价值的新型抗肿瘤先导化合物。
Aim： To synthesize a new class of anti-tumor active compounds in order to obtain more efficient, low toxicity targeted anti-turnor lead drugs. Methods： By synthesizing two kinds of suitable porphyrin molecules first and then connecting with chrysin derivatives through different carbon chains with ether bonds to formation of a new type of porphyrin-chrysin complex. We confirmed the structure of the compounds by nuclear magnetic resonance spectroscopy and UV/vis spectrum. Compounds were then tested for their activity against breast cancer MCF-7 cells in vitro using standard MTT assays. Results： Four new porphyrinchrysin complexes were successfully synthesized; their anti-tumor activity was better than that of the parent compound by MTT assay. Conclusion： This topic has synthesized a new class of anti-tumor potential compounds with in-depth research value.
作者
刘鼎
何军
成林
张奇志
刘运美
Liu Ding;He Jun;Cheng Lin;Zhang Qizhi;Liu Yunmei(Institute of Pharmacy ＆ Pharmacology, University of South China, Hengyang 421101;Institute of Chemistry ＆ Chemical Engineering, University of South China, Hengyang 421101, China)
出处
《广东化工》
CAS
2018年第7期51-52,88,共3页
Guangdong Chemical Industry
基金
湖南省自然科学基金资助项目(2018JJ2349)
湖南省教育厅基金(No.14C1003)资助项目
湖南省大学生研究性学习和创新性实验计划项目(2017205351)资助项目
关键词
卧啉
白杨索
抗肿瘤
合成
Porphyrin
Chrysin
Anti-tumor
synthesis
