摘要
目的研究注射用益气复脉(冻干)的化学成分。方法采用超高效液相色谱仪-质谱(UPLC-Q-TOF/MS)方法对注射用益气复脉(冻干)成分进行分析,通过各色谱峰的质谱数据与Waters UNIFI数据库匹配,并结合二级碎片的裂解规律和文献报道进行解析。结果从注射用益气复脉(冻干)中共鉴定出145个化合物,其中有26个药效成分为首次检出,包括17个黄酮类化合物,4个麦冬皂苷类化合物以及5个木脂素类化合物。结论 UPLC-Q-TOF/MS法可以快速、有效的鉴别注射用益气复脉(冻干)的相关成分,为中药质量控制提供依据。
Objective To study the chemical constituents of Yiqi Fumai Lyophilized Injection. Methods The constituents of Yiqi Fumai Lyophilized Injection were analyzed by UPLC-Q-TOF/MS. The mass spectra of each peak were matched with the Waters UNIFI database, and the cracking rules of the second-level fragments and related literatures were used for identification. Result A total of 145 compounds were identified. Therein 26 active ingredients were first reported from Yiqi Fumai Lyophilized Injection,including 17 flavonoids, 4 ophiopogon japonicosides and 5 lignans. Conclusion UPLC-Q-TOF/MS can be used to identify the active ingredients of Yiqi Fumai Lyophilized Injection rapidly and efficiently, and the result can be provided a basis for TCM quality control.
作者
周垚垚
焦燕婷
王彦帅
侯媛媛
李德坤
周大铮
鞠爱春
白钢
ZHOU Yaoyao;JIAO Yanting;WANG Yanshuai;HOU Yuanyuan;LI Dekun;ZHOU Dazheng;JU Aichun;BAI Gang(College of Pharmacy, Nankai University, Tianjin 300353, China;Tianjin Tasly Pride Pharmaceutical Co. Ltd., Tianjin 300402, China)
出处
《药物评价研究》
CAS
2018年第3期446-450,共5页
Drug Evaluation Research
