摘要
近年来的研究发现,细菌应答抗生素压力时会产生特异的非编码小RNA(small RNA,sRNA)谱,进而可能调控下游基因的表达,帮助细菌克服抗生素压力。sRNA以各种方式调控细菌耐药相关基因(如抗生素转运蛋白、药物外排泵、细胞被膜的合成与修饰),参与细菌耐药网络。因此,sRNA及其相关因子(如Hfq)可能被用作抗菌治疗的靶标。本文将从sRNA应答抗生素压力并产生抗生素耐药及其作为药物靶点的前景等方面,综述sRNA在细菌耐药调控方面的研究进展。
Recent studies have found that bacteria respond with generating a special non-coding small RNA （small RNA, sRNA） repertoire to antibiotic stress, which may regulate the downstream gene and help the bacteria overcome the antibiotic challenge. Then, sRNA are involved in bacterial resistance network by regulating bacterial resistance related genes （such as antibiotic transporters, drug effiux pumps, synthesis and modification of cell envelope） in various ways. Thus, sRNA and its partners （such as Hfq） may be used as targets for antimicrobial therapy. In this review, we will address the role of sRNA in responding to antibiotic stress, generating antibiotic resistance and prospects as drug targets to elaborate the progress of sRNA in bacterial resistance regulation.
作者
洪守强
李娜
方鼎丽
王岱
Hong Shou-qiang;Li Na;Fang Ding-li;Wang Dai(State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Xiamen University, Xiamen 361102)
出处
《中国抗生素杂志》
CAS
CSCD
2018年第4期408-414,共7页
Chinese Journal of Antibiotics
基金
国家自然科学基金(No.31370166、No.81473251和No.81301474)
福建省自然科学基金(No.2015J01345和No.2014J01139)
厦门大学校长基金(No.20720160060)
