摘要
番木瓜(Carica Papaya)是一种极具营养价值而被广泛种植的热带水果,其籽中含有苄基硫代葡萄糖苷(Glucosinolate,GS),约占番木瓜重量7%,是果肉加工的废弃物。GS主要存在于细胞空泡,当其接触到芥子酶就会被水解,生成异硫氰酸酯类(Isothiocyanates,ITCs)。ITCs是十字花科植物的次生代谢产物,是一类重要的有机合成中间体,公认具有防癌抗癌功效以及抑菌作用,异硫氰酸苄酯(Benzyl isothiocyanate,BITC)是ITCs中生物学效果最为明显的一种。BITC对许多癌症有明显的抑制作用,可以阻断癌细胞增殖分化;BITC对致病菌有抑制甚至杀死作用,这种抑菌活性可以作用于细菌和霉菌。本文结合国内外相关研究现状,综述BITC在防癌抗癌及抑菌方面的研究进展,为番木瓜籽副产物BITC更深一步的加工以及番木瓜综合利用率的提升提供一定的理论依据。
Carica Papaya is one of the widely cultivated tropical fruits with high nutritious values. As the waste of papaya pulp processing, papaya seeds contain glucosinolates, which account for about 7% of papaya weight. Glucosinolates mainly present in cellular vacuoles, which can be hydrolyzed to produce isothiocyanates（ITCs） when exposed to mustard enzymes. ITCs is a secondary metabolite of cruciferae with anti-cancer and antibacterial effects and also an important intermediate in organic synthesis. The benzyl isothiocyanate（BITC） is one of the most obvious biological effects in ITCs. BITC has a significant inhibitory effect on many cancers by blocking the proliferation and differentiation of cancer cells; and it can inhibit or even kill the pathogenic bacteria, which can act on bacteria and moulds. This review summarizes the research progress of anticancer and antibacterial functions of BITC,, and provides some theoretical basis for further processing of byproduct of papaya seed BITC as well as the improvement of comprehensive utilization rate of Carica Papaya.
作者
朱华平
赵毅蒙
李超
李文钊
刘玉茜
ZHU Hua-ping;ZHAO Yi-meng;LI Chao;LI Wen-zhao;LIU Yu-qian(China Rural Technology Development Center, Beijing 100045, China;Key Laboratory of Food Nutrition and Safety, Ministry of Education, College of Food Engineering and Biotechnology, Tianjin University of Science ＆ Technology, Tianjin 300457, China)
出处
《现代食品科技》
EI
CAS
北大核心
2018年第3期270-275,261,共7页
Modern Food Science and Technology
基金
国家自然科学基金资助项目(31501532)
关键词
番木瓜籽
异硫氰酸苄酯
防癌抗癌
抑菌
papaya seed
benzyl isothiocyanate
anti-cancer
antibacterial
