摘要
目的:观察炔雌醇环丙孕酮片对多囊卵巢综合征(PCOS)患者血清抗苗勒氏管激素(AMH)的影响。方法:选取2015年1月~2017年6月在上海市第六人民医院东院妇科门诊就诊的年龄20~30岁的PCOS患者63例。患者签署知情同意书后,予以炔雌醇环丙孕酮片治疗3个月。观察治疗前后内分泌、代谢参数的变化,并与年龄、体重匹配的健康女性比较。结果:63例PCOS患者中,50例完成了本研究。治疗前,PCOS患者的血清AMH水平显著高于对照组[(10.87±4.47)ng/ml vs(8.35±4.25)ng/ml,P<0.05],但正常体重患者和超重/肥胖患者之间,血清AMH水平无显著差异。炔雌醇环丙孕酮片治疗3个月,患者的血清AMH显著下降,差异有统计学意义[(8.22±3.03)ng/ml vs(10.85±3.98)ng/ml,P=0.000]。结论:短期使用炔雌醇环丙孕酮片能显著降低PCOS患者的血清AMH水平。
Objective：To observe the impact of ethinylestradiol cyproterone on serum anti-Müllerian hormone levels in women with polycystic ovarian syndrome. Methods： Women with PCOS of age 20 to 30 who attended to outpatient department of Gynecology of Shanghai Sixth People＇s Hospital East Campus from January 2015 to June 2017 were enrolled. After informed consents were signed,patients were prescribed with ethinylestradiol cyproterone for 3 months.Endocrine and metabolic parameters were compared before and after treatment.Age and BMI matched healthy women were recruited as control.Results：Fifty from 63 patients completed the study.Serum AMH was significant increased in PCOS than control group before treatment[（10.87±4.47）ng/ml vs（8.35±4.25）ng/ml,P〈0.05],but no difference were found between normal weight and overweight/obese patients. Serum AMH was significantly decreased after 3 month of treatment[（10.85±3.98） ng/ml vs（ 8.22±3.03） ng/ml,P = 0.000]. Conclusion：Serum AMH levels were significantly decreased after short-term treatment with ethinylestradiol cyproterone.
作者
熊苗
朱海润
罗艳群
陆继红
王军
黄红玲
李莉
刘阳
陈宇
朱洁萍
Xiong Miao;Zhu Hairun;Luo Yanqun et al(Shanghai Sixth People＇s Hospital East Campus, Shanghai 201306;Guangming Chinese Medicine Hospital of Pudong New Area,Shanghai 201300)
出处
《现代妇产科进展》
CSCD
北大核心
2018年第3期195-197,共3页
Progress in Obstetrics and Gynecology
基金
上海市浦东新区卫计委联合攻关项目的资助(No:PW2013D-6)
