摘要
目的：利用SPSS 20.0提供的描述性分析进行数据挖掘了解吴茱萸在现代临床应用上的剂量情况及量效关系,并与2015年版《中华人民共和国药典》中规定的吴茱萸剂量作对比分析。方法：文献检索近17年期间在国内公开发表的中医应用吴茱萸的中医医家临床经验、病例报道和临床观察文献,采用均数、百分位数（Px）和极差（R）等统计方法对中医医家运用吴茱萸的剂量进行描述性分析。结果：吴茱萸的剂量阈为2 g,治疗窗为2~30 g,平均使用剂量值为9.71 g,其中77.96%（336/431）分布在6~15 g之间。当患者有头痛或眩晕时,其常用剂量为6~15 g;恶心、呕吐时,其常用剂量为6~12 g;反酸时,其常用剂量范围为3~5 g。结论：研究发现吴茱萸在汤剂中的剂量阈和治疗窗可适当提高或扩宽,以6~15 g为宜。相比而言,《中华人民共和国药典》所规定的2~5g的剂量使用范围明显偏低、偏窄。数据挖掘结果较客观地反映、总结了吴茱萸在现代临床应用中的量效关系,有助于推动吴茱萸在临床中的合理应用。
Objective： To explore the current dose of Wuzhuyu prescribed in clinic and its dose-effect relationship based on data mining by SPSS 20. 0 in descriptive analysis and comparatively analyze the dose stipulated by Pharmacopeia of the People＇ s Republic of China（ 2015 Version）. Methods： The clinical experiences,case reports and clinical observation literature related to Wuzhuyu＇s application in recent 17 years were retrieved from Chinese national knowledge infrastructure. The mean value,percentiles,range and so on were used to descriptively analyze the dose of Wuzhuyu by traditional Chinese medicine physicians. Results：The threshold dose of Wuzhuyu was 2 g. The effective treatment window about the Wuzhuyu was 2 ~ 30 g and the average dose was9. 71 g. By analysis,77. 96% of Wuzhuyu prescribed in clinic was distributed ranging from 6 g to 15 g. If headache or vertigo,the commonly-used dose of Wuzhuyu was 6 ~ 15 g; for nausea and vomiting,its commonly-used dose was 6 ~ 12 g; for acid regurgitation,its commonly-used dose was ranged from 3 ~ 5 g. Conclusion： It is indicated that the threshold dose and the effective treatment window for Wuzhuyu in decoction can be increased and expanded,and 6 ~ 15 g is the appropriate dose in clinic. The stipulated dose of Wuzhuyu in Chinese Pharmacopeia is 2 ~ 5 g,which is greatly lower and narrowed than that used in clinical practice.The data mining objectively reflects the dose-effect relationship of Wuzhuyu in modern clinical application,which is helpful to promote the rational use of traditional Chinese herbs like Wuzhuyu in clinic.
作者
裴相俊
倪胜楼
金珉串
宋佳
傅延龄
PEI Xiangjun1 ,NI Shenglou2 ,JIN Minchuan1 ,SONG Jia1 ,FU Yanling1(1. TCM School, Beijing University of Chinese Medicine, Beijing 100029, China ;2. The Journal Center of Beijing University of Chinese Medicine, Beijing 100029, Chin)
出处
《辽宁中医杂志》
CAS
2018年第3期525-528,共4页
Liaoning Journal of Traditional Chinese Medicine
基金
国家重点基础研究发展计划(973计划)(2010CB530604)
关键词
吴茱萸
量效关系
临床观察
Wuzhuyu
dose - effect relationship
clinical observation
