摘要
肿瘤细胞周期治疗时代已经来临。直接调节细胞周期的蛋白如细胞周期素依赖性激酶(CDKs)、检查点激酶(CHK)、Aurora激酶、Polo样激酶和WEE1激酶是细胞周期治疗药物的主要靶标。除了阻滞细胞周期从G1期进入S期外,细胞周期治疗还能够激活抗肿瘤免疫、控制代谢功能和调节转录水平。细胞周期治疗与激素药物、磷脂酰肌醇-3激酶(PI3K)抑制剂、表皮生长因子(EGFR)抑制剂和自噬抑制剂的联合应用提高了肿瘤内科治疗的效果。在整合基因组学时代,细胞周期治疗为肿瘤精准治疗增加了新内容。本文对肿瘤细胞周期治疗的主要靶标和作用机制进行综述。
The era of cancer cell-cycle therapeutics has come. Proteins that directly regulate cell cycle progression, such as cyclin-de- pendent kinases （CDKs）, checkpoint kinases（CHKs）, Aurora kinases, Polo-like kinases, and the WEE1 kinase, are the main targets of cell- cycle therapeutics. In addition to the regulation of G1-S-phase progression, cell-cycle therapeutics also trigger anti-tumor immunity, regulate metabolism, and control transcription reprogramming. Combinations of cell cycle therapeutics with hormone therapy, phosphatidylinositol 3-kinase （PI3K） inhibitors, epidermal growth factor receptor {EGFR） inhibitors, and autophagy inhibitors provide new therapeutic strategies for cancer treatment. Cancer cell-cycle therapeutics constitute a novel strategy for precision oncology in the age of integrative genomics. This review basically summarizes the targets and mechanisms of cancer cell-cycle therapeutics.
作者
张百红
岳红云
Baihong Zhang;Hongyun Yue(Department of Oncology;Department of Ophthalmology, Lanzhou General Hospital of Lanzhou Military Region, Lanzhou 730050, China)
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2018年第6期316-319,共4页
Chinese Journal of Clinical Oncology
基金
甘肃省自然科学基金项目(编号:1308RJZA181)资助~~
关键词
肿瘤
治疗
细胞周期
neoplasms, therapeutics, cell cycle
