摘要
目的了解苏州市急性呼吸道感染住院儿童的病毒病原谱及流行特征。方法对2016年11月~2017年5月入住医院呼吸科的儿童进行前瞻性监测,采集研究对象的鼻咽分泌物,检测甲、乙型流感病毒(influenza virus A and B,Inf A、Inf B)、呼吸道合胞病毒(respiratory syncytial virus,RSV)、腺病毒(adenovirus,ADV)、副流感病毒(parainfluenza virus,PIV)、鼻病毒(rhinovirus,RV)和博卡病毒(bocavirus,Bo V)抗原,同时收集人口学信息和临床资料。结果研究共纳入479名病例,病毒总检出率为49.1%(235/479),检出率最高的为RSV 26.1%(125/479),其次为流感病毒(7.7%),RV(7.3%),Bo V(5.2%),PIV(4.6%)和ADV(1.5%)。Inf A主要是H3N2,Inf B主要为Victoria株系。7~月龄组患儿的病毒检出率最高(59.6%),其次为0~月龄组(55.8%),检出率随年龄增长逐渐降低(X_(趋势)~2=13.541,P=0.001)。结论苏州市儿童急性呼吸道感染以RSV为主,流感病毒也起着重要作用,Inf A以H3N2为主,Inf B以Victoria为主。低年龄儿童更容易受呼吸道病毒感染,部分病毒感染有年龄和季节差异。
Objective To investigate the viral etiology of hospitalized children with acute respiratory infection in Suzhou. Methods A prospective study of hospitalized patients in the respiratory department of Soochow University affilia- ted children＇ s hospital from November 2016 to May 2017 was conducted. We enrolled the patients based on strict inclusion criteria, such as local residents, disease occurred within 7 days and without admission in the previous 30 days. The nasopharyngeal secretions were collected for detection of influenza virus A and B （ InfA ＆ InfB） by Real-time fluorescence RT- PCR, respiratory syncytial virus （RSV）, adenovirus （ADV）, parainfluenza virus （PIV） and rhinovirus （RV） by direct immunofluorescence （DFA）, as well as bocavirus （BoV） by Real-Time PCR..We also collected the demographic and clin- ical information, and analyzed the epidemiological characteristics of tested respiratory viruses. Results A total of 479 samples were collected, and the grant positive rate of respiratory virus was 49. 1% （235/479）. RSV was the most common virus （26. 1% ）, followed by influenza virus （7. 7% ）, RV （7. 3% ）, BoV （5.2%）, PIV （4. 6% ） and ADV （1.5%）. The positive rate of respiratory virus was highest in children aged 〉 6 to ≤ 12 months old （59. 6% ）, followed by≤6 2 months of age （55.8%）. The positive rate of respiratory virus decreased with age （ Х^2Trend = 13. 541 ,P = 0. 001 ）. Conclusions RSV was the most common virus and influenza virus also played an important role in acute respiratory infections among children in Snzhou. Influenza A/H3N2 and influenza B/Victoria was prevalent at this season. The very young children were more susceptible to respiratory viral infection. Significant differences in age and time were observed in some respiratory virus infections.
作者
单玮
严永东
陈立凌
陈正荣
陈凯乐
刘长鹏
张钧
赵根明
张涛
SHAN Wei;YAN Yong-dong;CHEN Li-ling;CHEN Zheng-rong;CHEN Kai;le;LIU Chang-peng;ZHANG Jun;ZHAO Genruing;ZHANG Tao(Department of Epidemiology, School of Public Health, Fndan University, Shanghai 200032, China;Key Laboratory of Public Health Safety, Ministry of Education, Shanghai 200032, China;Collaborative Innovation Center of Social Risks Governance in Health, Shanghai 200032 China;Department of Respiration, Soochow University Affiliated Children＇ s Hospital, Suzhou 215003, China;Department of Infectious Diseases Control, Suzhou Center of Disease Control and Prevention, Suzhou 215004, China)
出处
《中华疾病控制杂志》
CAS
CSCD
北大核心
2018年第4期335-339,共5页
Chinese Journal of Disease Control & Prevention
基金
全球流感医院监测网(CN20162017)
中美新发和再发传染病合作项目(5U2GGH000018)
上海市第四轮公共卫生三年行动计划高端海外研究团队项目(GWTD2015S05)
上海市卫计委公共卫生重点学科项目(15GWZK0101)
关键词
急性呼吸道感染
病毒
流行病学研究
儿童
Acute respiratory infection
Virus
Epidemiological studies
Children
