摘要
目的对≥65岁与〈65岁肺结核患者的治疗效果进行对比分析，为制定相应的结核病防治策略提供依据。方法选择我国8个省共49个实施单位确诊的2075例涂阳肺结核患者进行分析，其中≥65岁肺结核患者282例，年龄范围65-91岁，平均年龄（73．6±16．4）岁，〈65岁肺结核患者1793例，年龄范围15～64岁，平均年龄（38．3±18．6）岁，采用卡方检验及Fisher精确概率检验比较≥65岁及〈65岁肺结核患者在不良反应、病灶吸收、空洞闭合、2个月末痰培养及治疗转归方面的差异，检验水准为0．05。结果在2075例涂阳肺结核患者中，≥65岁肺结核患者治疗后的不良反应率、病灶未吸收或恶化率分别为24．8％（70／282）及9．9％（20／203），高于〈65岁肺结核患者的22．0％（390／1793）及7．8％（111／1419），但差异无统计学意义（χ2值分别为0．249及0．248，P值均〉0．05）；≥65岁肺结核患者空洞未闭合及增大、2个月末阴转率及治疗失败率分别为17．6％（13／74）、20．2％（44／218）及12．8％（36／282），明显高于〈65岁肺结核患者的8．9％（51／575）、14．6％（217／1491）及7．8％（139／1793），差异有统计学意义（χ2值分别为0．041、0．034及0．001，P值均〈0．05）。结论65岁及以上老年肺结核患者与65岁以下年龄组相比，其不良反应发生率、空洞恶化及病灶未吸收比率、2个月末未阴转率较高，治疗转归更差。
Objective To analyze treatment effect between aged 65 and above and under aged 65 years with pulmonary tuberculosis patients, and provide reference for tuberculosis prevention and control strategy. Methods Two thousand and seventy five patients diagnosed and treated from 8 provinces were enrolled in the study, 282 patients were 65 years old and above,ranging from 65 to 91 years old with an average of （73.6±16.4） years old. 1793 cases were under 65 years old ranging from 15 to 64 years old with an average （38.3±18. 6） years old among 2075 patients. Chi-square test and Fisher exact test were used to compare the following variables between aged 65 and above and under aged 65 years with pulmonary tuberculosis patients： adverse reactions （ADR）, cavity closure, lesions absorption, sputum-culture results at the end of the 2nd month of treatment, and treatment outcome. A P-value of less than 0. 05 is considered statistically significant. Results Sixty five years old and above patients accounted for 13.6% （282/2075）, ADR rate, no change and deterioration of lesions among aged 65 and above group was 24.8% （70/282） and 9.9% （20/203） respectively and was higher than under 65 years old group which was 22. 0% （390/1793） and 7. 8% （111/1419）, but the difference was not significant （ge value was 0. 249 and0. 248,respectively; P-value 〉0.05） ;meanwhile no change and deterioration of cavities, sputum-culture rate at the end of the 2nd month of treatment and failure rate among aged 65 and above group were 17.6% （13/74）, 20.2% （44/218） and 12.8% （36/282） respectively, was significant higher than under 65 years old non-elderly group which was 8.9%（51/575） ,14. 6%（217/1491） and 7.8% （139/1793）（χ2 value was 0. 041, 0. 034 and 0. 001,respectively; P-value 〈0. 05）. Conclusion Treatment effect aged 65 and above group was inferior to those under 65 years old group with higher ADR rate, higher deterioration of lesions and cavities, higher sputum-culture rate at the end
作者
马艳
黄麦玲
杜建
舒薇
谢仕恒
王红红
谭守勇
李向群
傅衍勇
马丽萍
张联英
刘飞鹰
胡代玉
张艳玲
刘宇红
李亮
MA Yan, HUANG Mai-ling, DUJian, SHUWei, XIE Shi-heng, WANG Hong-hong, TAN Shou-yong, LI Xiang-qun, FU Yan-yong, MA Li-ping, ZHANG Lian-ying, LIU Fei-ying, HU Dai-yu, ZHANG Yan-ling, LIU Yu-hong, LI Liang.(Center Office, Beijing Tuberculosis and Thoracic Tumor Research Institute/Clinical Center on Tuberculosis, Chinese Center for Disease Control and Prevention, Beijing Chest Hospital, Capital Medical University, Beijing 101149, Chin)
出处
《结核病与肺部健康杂志》
2018年第1期54-59,共6页
Journal of Tuberculosis and Lung Health
基金
“十一五”国家科技重大专项(2008ZX10003-008-02)
关键词
老年人
结核
肺
年龄组
疗效比较研究
Aged
Tuberculosis, pulmonary
Age groups
Comparative effectiveness research
