摘要
目的探讨超声乳化联合非球面散光矫正型多焦点人工晶状体（IOL）植入术对老年糖尿病性白内障患者术后视功能及氧化应激反应的影响。方法选取糖尿病性白内障患者74例，随机分为对照组和研究组，每组37例。对照组采用角膜缘松解术联合小切口白内障囊外摘除术＋球面IOL植入术，研究组采用超声乳化＋非球面散光矫正型多焦点IOL植入术。入院时及术后3个月随访时统计对比两组视功能指标[最佳矫正近视力（BCNVA）、非矫正近视力（UCNVA）、最佳矫正远视力（BCDVA）、非矫正远视力（UCDVA）]、散光、手术前后血清氧化应激反应指标[丙二醛（MDA）、谷胱甘肽过氧化物酶（GSH-Px）、超氧化物歧化酶（SOD）]变化情况及并发症发生率。结果术后两组BCNVA、UCNVA、BCDVA、UCDVA均较术前增高，且研究组UCNVA高于对照组，差异有统计学意义（P〈0．05）；其余各指标与对照组比较，差异未见统计学意义（P〉0．05）。术后两组散光程度较术前减小，且研究组小于对照组，差异有统计学意义（P〈0．05）。术后两组血清GSH-Px、SOD水平较术前降低，MDA水平较术前增高；但研究组血清GSH—Px、SOD水平高于对照组，MDA水平低于对照组，差异有统计学意义（P〈0．05）。研究组并发症发生率[10．81％（4／37）]与对照组[13．52％（5／37）]比较差异未见统计学意义（P〉0．05）。结论采用超声乳化联合非球面散光矫正型多焦点IOL植入术治疗老年糖尿病性白内障效果显著，可改善患者视功能及散光程度，减轻氧化应激反应，且并发症发生率较低，值得临床推广。
Objective To investigate the effect of ultrasonic phacoemulsification combined with multifocal aspherie toric intraocular lens （IOL） implantation on postoperative visual function and oxidative stress in elderly patients with diabetic cataract. Methods Seventy-four patients with diabetic cata- ract were randomly divided into control group and study group, with 37 cases in each group. The control group was treated by corneal limbus lysis combined with small-incision extracapsular cataract extraction spherical IOL implantation, the study group was treated by phaeoemulsification and muhifocal aspheric toric IOL implantation. Visual function indicators [ best corrected near vision （BCNVA） , uncorrected near vision （UCNVA）, best corrected distant visual acuity （BCDVA）, uncorrected distant vision acuity （UCDVA） ], astigmatism, preoperative and postoperative serum oxidative stress response [ malondialde- hyde （MDA）, glutathione peroxidase （GSH-Px） and superoxide dismutase （SOD） ] levels, and the incidence of complications were statistically compared between the two groups at the time of admission and 3 months after treatment. Results The BCNVA, UCNVA, BCDVA and UCDVA levels in the two groups after operation were significantly higher than those before operation, and UCNVA in study group was significantly higher than that in control group, differences were significant （ P 〈 0. 05 ） ; and there was no significant difference in the rest indexes between study group and control group （ P 〉 0. 05 ）. The astigmatism degree in two groups decreased after operation, and astigmatism degree in study group was smaller than that in control group, the difference was statistically significant （ P 〈 0. 05 ）. The levels of serum GSH-Px and SOD in the two groups after operation were lower than those before operation, and the MDA level was higher than that before operation, however, the levels of serum GSH-Px and SOD in study group were higher than those in control group, the MDA level was lo
作者
谢可
王骞
刘建君
陈鹏
Xie Ke, Wang Qian, Liu Jianjun, Chen Peng(Department of Cataract, the Second People＇ s Hospital of Zhengzhou, Zhengzhou 450000, Chin)
出处
《中国实用医刊》
2018年第1期53-57,共5页
Chinese Journal of Practical Medicine
关键词
超声乳化
非球面散光矫正型多焦点人工晶体植入术
糖尿病性白内障
视功能
氧化应激反应
Ultrasonic phacoemulsification
Muhifocal aspheric toric intraocular lens implantation
Diabetic cataract
Visual function
Oxidative stress response
