摘要
目的探讨甲状旁腺全切术（厕）加自体前臂移植术（AT）治疗慢性肾脏病5期（CKD一5）继发性甲状旁腺功能亢进症（SHPT）的疗效。方法选取行，TPTX＋AT的CKD-5期患者86例，检测患者术前及术后血钙、血磷、血碱性磷酸酶、血全段甲状旁腺激素（iPTH）水平，分析其手术前后变化情况。分析患者术前骨痛等临床症状及术后症状缓解情况。结果术后病理结果提示甲状旁腺增生224枚，甲状旁腺瘤119枚。手术前后血清钙、血清磷、iPTH水平比较差异均有统计学意义（P均〈0．01），术前及术后半年碱性磷酸酶水平比较差异有统计学意义（P〈0．01）。结论甲状旁腺全切术加自体前臂移植术可有效阻断SHPT，显著改善患者顽固性骨痛等症状。
Objective To discuss the effects of total parathyroidectomy （TPTX） combined with forearm autotransplantation （AT） on patients with chronic kidney disease stage 5 （ CKD-5 ） with seconda- ry hyperparathyroidism （SHFF）. Methods Eight-six patients with CKD-5 who underwent TPTX ＋ AT were selected, levels of blood calcium, serum phosphatase, alkaline phosphatase （ ALP）, blood impact segment parathyroid hormone （iFFH） before and after operation were detected and analyzed. Clinical symptoms like preoperative ostealgia and postoperative remission were analyzed. Results Postoperative pathological results suggested 224 cases of parathyroid hyperplasia, 119 cases of parathyroid adenoma. There were significant differences in levels of serum calcium, serum phosphatase and iPTH before and after operation （ all P 〈 0. 01 ）, and there was significant difference in preoperative alkaline phosphatase before and half year after operation （P 〈 0. 01 ）. Conclusions TFFX ＋ AT can effectively block SHPT and alleviate ostealgia and other symptoms.
作者
郑守华
李建华
刘沛
付利军
邱新光
张水军
Zheng Shouhua, Li Jianhua, Liu Pei, Fu Lijun, Qiu Xinguang, Zhang Shuijun(Department of General Surgery, the Fist Affiliated Hospital of Zhengzhou University, Zhengzhou 4500521 Chin)
出处
《中国实用医刊》
2018年第1期15-16,共2页
Chinese Journal of Practical Medicine
基金
河南省郑州市科技局科技攻关计划（N2014S0053）
