摘要
非酒精性脂肪肝病(NAFLD)是最常见的慢性肝病之一,属于肝脂肪变性(NAFL)和脂肪性肝硬化(NASH)之间的过渡型的病理类型。目前普遍认为,炎症是导致NAFLD的一个重要而不可忽略的发病诱因。最新研究发现,白介素(IL)-17及其家族成员和网络式的信号通路,通过诱发炎症和导致脂质代谢异常,成为NAFLD的新的发病机理之一。肥胖人群,辅助性T细胞17(TH17)细胞有明显增多趋势,同时IL-17也是高表达的,反之,减少该类细胞或者基因敲除IL-17基因,可以减少炎症发生和患者体重增加。
Non-alcoholic fatty liver disease（NAFLD） is one of the most common chronic liver diseases, and it is a transitional pathological type between hepatic steatosis（NAFL） and fatty liver cirrhosis（NASH）. It is widely believed that inflammation is an important and non negligible cause of NAFLD. Recent studies have found that interleukin（IL）-17 and its family members and network-like signaling pathways have become one of the new pathogenesis of NAFLD by inducing inflammation and leading to abnormal lipid metabolism. The T helper cell 17（TH17） cells in the obese population were significantly increased, and IL-17 was also highly expressed. On the other hand, reducing this type of cell or knocking out the IL-17 gene can reduce the incidence of inflammation and increase the weight of the patient.
作者
卫星
李明
谭国群
WEI Xing, LIMing, TAN Guo-qun(Department of Clinical Laboratory, Chongqing Wuxi County People＇s Hospital, Chongqing 405800, Chin)
出处
《中国实用医药》
2018年第10期188-191,共4页
China Practical Medicine
关键词
白介素17
炎症
非酒精性脂肪肝病
肥胖
Interleukin 17
Inflammation
Non-alcoho!ic fatty liver disease
Obesity
