摘要
目的分析4例原发性椎管内淋巴瘤的临床特点。方法收集2014年2月至2017年2月河南省人民医院经手术病理证实的原发性椎管内淋巴瘤患者4例，回顾性分析其临床表现、影像学特点及病理特征，并文献复习。结果患者的主要临床表现为持续性或间断性腰（背）疼痛，伴双下肢无力，感觉减退或消失，大小便失禁，并有神经功能短期进行性加重恶化。影像学表现为单发的梭形或不规则肿物，T1WI上呈等信号或稍低信号，T2WI呈等或略高信号，一般信号均匀；增强后呈均匀轻中度强化。本组4例病理活体组织检查结果均为B细胞来源的非霍奇金淋巴瘤。结论原发性椎管内淋巴瘤临床表现和影像学表现缺乏特异性，容易误诊，确诊主要依靠病理活体组织检查。
Objective To analyze clinical characteristics of four cases with primary intraspinal lymphoma to achieve early diagnosis of the disease. Methods Clinical data including the clinical presentation, imaging features and pathological characteristics of four patients diagnosed as primary intraspinal lymphoma confirmed surgically and pathologically from February 2014 to February 2017 in Henan Provincial People＇ s Hospital were analyzed retrospectively, and literatures were reviewed. Results The major clinical manifestations of the primary intraspinal lymphoma were as following ： persistent or intermittent waist （back） pain, accompanied with both lower limb weakness, dysfunction of motion, loss or disappearance of sensation, incontinence, followed by an acute progressive neurological function deterioration. The imaging showed a single fusiform shape or irregular lump. The TL WI signal was equal or slightly lower, and T2WI showed equal or slightly higher signal, and the general signal uniform;The lump showed mild or moderate homogeneous enhancement. The group of four cases were B cell non-Hodgkin lymphoma confirmed by pathological biopsy. Conclusions The clinical and imaging features of primary intraspinal lymphoma are lack of specificity and are easy to be misdiagnosed. The diagnosis is mainly based on pathological biopsy.
作者
杨红
臧卫周
夏明荣
孙雅静
张杰文
Yang Hong , Zang Weizhou, Xia Mingrong, Sun Yajing,(Zhang Jiewen Xinxiang Medical College, Xinxiang, Henan 453003, Chin)
出处
《中华神经科杂志》
CAS
CSCD
北大核心
2018年第4期288-293,共6页
Chinese Journal of Neurology
基金
2015年河南省科技攻关计划项目（152102310140.0）
