摘要
射频消融(RFA)是目前广泛应用于不可切除肿瘤的微创、有效的治疗方法 ,近20年来取得了显著进展,但治疗较大肿瘤仍存在一定局限性。随着纳米技术进步,纳米载体药物可提高肿瘤局部药物浓度,降低不良反应,在肿瘤治疗领域取得了较大成就,并在与RFA联合应用领域得到迅速发展。本文综论了纳米药物在肿瘤RFA中研究现状,主要包括脂质体载药、纳米胶束载药、纳米微球载药、碳纳米管载药及纳米金颗粒载药系统,并展望新的研究方向,以提高RFA治疗效果。
Radiofrequency ablation （RFA） is a minimally-invasive and effective treatment which is widely used for unresectable tumors at present. Significant progress in clinical practice of RFA has been made in the past 20 years, but there are still some limitations for the treatment of larger tumors. With the development of nanotechnology, the use of nano-carrier drugs can increase local drug concentration within tumor and reduce adverse reactions. Nanotechnology has already made great achievements in the field of cancer treatment, and it has been developing rapidly in the field of joint application with RFA. In order to improve the curative effect, this paper summarizes the current research status of nanopartieulate system adopted in tumor RFA, including liposome-loaded drugs, nano-micelle loaded drugs, nano-microspheres loaded drugs, carbon nanotube loaded drugs and gold nanoparticles drug delivery system, and the prospect of new research directions will also be discussed.
作者
姜安娜
杨薇
JIANG Anna, YANG Wei.(Department of Ultrasound, Peking University Cancer Hospital ＆ Institute, Key Laboratory of Carcinogenesis and Translational Research （Ministry of Education）, Beijing 100142, China)
出处
《介入放射学杂志》
CSCD
北大核心
2018年第4期295-298,共4页
Journal of Interventional Radiology
基金
国家自然科学基金(81471768、81773286)
关键词
肿瘤
射频消融
纳米颗粒
联合治疗
tumor
radiofrequency ablation
nanoparticle
combination therapy
