摘要
目的比较不同抗生素治疗方案对慢性盆腔炎的临床疗效及炎性因子水平的影响。方法选取慢性盆腔炎患者78例，采用电脑产生试验病例随机号码法分为观察组（抗生素序贯法）和对照组（抗生素序贯转化法），每组39例。治疗10d后，观察两组的临床疗效，对比治疗前后血清中IL-1（白介素-1）、IL-2（白介素-2）水平表达情况；并比较两组患者经济成本、用药期间不良反应发生情况，并于治疗结束6个月后随访两组患者复发情况。结果经过10d治疗后，观察组总有效率94．59％，对照组的总有效率为86．49％，观察组总缓解率高于对照组，差异有统计学意义（χ^2=5．41，P=0．00）。治疗前，观察组IL-1表达为（413．47±38．59）μg／L，IL-2表达水平为（489．43±44．58）ng／L，对照组IL-1表达为（419．47±40．46）μg/L，IL-2表达水平为（490．47±47．40）ng／L，两组治疗前IL-1（t=0．65，P=0．52）及IL-2（t=0．10，P=0．92）表达水平差异无统计学意义；治疗后，观察组IL-1表达为（288．53±32．48）μg／L，低于治疗前（t=15．07，P=0．00），IL-2表达水平为（288．53±32．48）ng／L，高于治疗前（t=14．65，P=0．00）。治疗后，对照组IL-1表达为（358．41±43．47）μg/L，低于治疗前（t=15．07，P=0．00），IL-2表达水平为（550．46±32．90）ng／L，高于治疗前（t=14．65，P=0．00）。观察组IL-1（t=7．83，P=0．00）及IL-2（t=9．66，P=0．00）改善情况均优于对照组。观察组药品成本及给药费用分别为（115．47±3．48）元、（27．45±2．01）元，对照组分别为（120．45±3．39）元、（27．45±2．01）元，两组药品成本（t=2．44，P=0．17）及给药费用（t=0．00，P=1．00）差异无统计学意义。观察组中2例患者出现胃肠道不适反应，对照组为1例，差异无统计学意义（χ^2=0．35，P=0．56）。两组发生的不良反应均�
Objective To compare the effects of different antibiotic regimens on clinical efficacy and inflammatory factors in patients with chronic pelvic inflammatory disease. Methods 78 patients with chronic pelvic inflammatory disease were enrolled. They were randomly divided into observation group （ antibiotic sequential method） and control group （ sequential transformation of antibiotics） by computer generation test case random number method, 39 cases in each group. After treatment for 10 days, the clinical efficacy was observed, the serum IL - 1 and IL - 2 levels before and after treatment were compared. The economic costs, adverse events during the course of treatment were compared between the two groups, and 6 months after treatment, the recurrence was followed up in the two groups. Results After 10 days of treatment, the total effective rate was 94. 59% in the observation group and 86. 49% in the control group. The total remission rate in the observation group was higher than that in the control group （ χ^2 = 5.41,P = 0. 002）. Before treatment, the levels of IL - 1 and IL - 2 of the observation group were （413.47 ± 38.59） μg/L, （ 489.43 ± 44.58） ng/L, respectively, which of the control group were （ 419.47± 40.46 ） μg/L, （490.47±47.40）ng/L, respectively, and the differences were not statistically significant between the two groups （t = 0. 65,0.10,P = 0.52,0. 92）. After treatment, the IL - 1 level of the observation group [ （ 288.53 ± 32.48 ） μg/L ] was lower than before treatment （ t = 15.07, P = 0.00）, and IL - 2 level [ （288.53 ± 32.48 ） ng/L ] was higher than before treatment （t = 14.65, P = 0.00）. After treatment, the IL - 1 level of the control group [ （358.41 ± 43.47 ）μg/L ] was lower than before treatment .（ t = 15.07, P = 0.00）, and IL - 2 level [ （ 550.46 ± 32.90 ） ng/L ] was higher than before treatment （t = 14.65 ,P = 0.00 ）. The improvement of IL- 1 and IL- 2 levels in the observation group were better than those in the control
作者
童美红
张涛
Tong Meihong,Zhang Tao.(Department of Pharmacy,the Maternal and Child Health Care Hospital of Fenghua District ,Ningbo ,Zhejiang 315500, China（ Tong MH） ;Department of Gynaecology,the Second Affiliated Hospital of School of Medicine ,Zhejiang University, Hangzhou , Zhejiang 310009, China （ Zhang T）)
出处
《中国基层医药》
CAS
2018年第8期1006-1009,共4页
Chinese Journal of Primary Medicine and Pharmacy
关键词
盆腔炎性疾病
抗感染药
白细胞介素类
Pelvic inflammatory disease
Anti-infective agents
Interleukins
