摘要
目的探讨2型糖尿病患者发生阿司匹林所致胃肠道出血的危险因素。方法回顾性分析2011年1月1日至2017年6月31日广州军区广州总医院内分泌科1 087例住院2型糖尿病患者的病历资料,均持续口服阿司匹林肠溶片100 mg/次,1次/d,服药时间≥7 d。发生胃肠道出血事件的患者归为出血组(152例),其余患者为非出血组(935例)。详细记录患者的各项临床资料并进行组间单因素分析和Logistic回归分析。结果单因素分析结果显示,出血组患者年龄、吸烟、饮酒、消化道疾病的构成比明显高于非出血组[(70±11)岁比(65±12)岁、74.3%(113/152)比63.4%(593/935)、40.8%(62/152)比25.8%(241/935)、18.4%(28/152)比7.8%(73/935)],差异均有统计学意义(均P<0.05)。Logistic回归分析结果显示,年龄(比值比=2.559,P=0.030,95%置信区间:1.093～5.989)和饮酒(比值比=2.039,P=0.023,95%置信区间:1.102～3.771)是2型糖尿病患者发生阿司匹林所致胃肠道出血的危险因素。结论高龄及长期饮酒是2型糖尿病患者发生阿司匹林所致胃肠道出血的高危因素。
Objective To analyze the risk factors of gastrointestinal bleeding caused by aspirin in patients with type 2 diabetes mellitus. Methods Totally 1 087 type 2 diabetic patients admitted from January 1st, 2011 to June 31st, 2017 in General Hospital of Guangzhou Military Command of People＇s Liberation Army were retrospectively analyzed; all patients took bayaspirin enteric-coated tablets 100 mg/time, 1 time/d. Gastrointestinal bleeding occurred in 152 cases （bleeding group）and 935 cases were non-bleeding group. Related indicators of aspirin-induced gastrointestinal bleeding were analyzed by single-factor test and logistic regression test. Results Age, smoking ratio, alcohol-drinking ratio and gastrointestinal disease ratio in bleeding group were significantly higher than those in non-bleeding group[ （70 ±11 ） years vs （ 65 ± 12） years, 74. 3% （ 113/152 ） vs 63.4% （ 593/935 ）, 40. 8% （62/152） vs 25.8% （241/935）, 18.4% （28/152） vs 7.8% （73/935） ] （P 〈0.05）. Logistic regression showed that advanced age（odds ratio =2. 559, P =0. 030, 95% confidence interval： 1. 093-5. 989） and alcohol-drinking （odds ratio = 2. 039, P = 0. 023, 95% confidence interval： 1. 102-3. 771 ） were risk factors of aspirin-induced gastrointestinal bleeding. Conclusion Advanced age and alcoh01-drinking are risk factors of gastrointestinal bleeding caused by aspirin in patients with type 2 diabetes mellitus.
作者
刘俊伟
李红梅
邓爱民
Liu Junwei, Li Hongmei, Deng Aimin(Department of Endocrinology, General Hospital of Guangzhou Military Command of People＇s Liberation Army, Guangzhou 510010, Chin)
出处
《中国医药》
2018年第3期397-399,共3页
China Medicine
关键词
2型糖尿病
胃肠道出血
阿司匹林
危险因素
Type 2 diabetes mellitus
Gastrointestinal bleeding
Aspirin
Risk factors
