摘要
目的:探讨茄尼醇对大鼠实验性牙周炎的影响。方法:选取SD大鼠126只,随机分为正常组(N组),牙周炎组(P组)、维生素C组(Vit C组)、茄尼醇低剂量组(S1组)、中剂量组(S2组)、高剂量组(S3组)。灌胃给药第2、4、6周,随机抽取6只,采血检测血浆中IL-1β、TNF-α、PGE2、SOD、GSH-Px、MDA水平;测量大鼠牙槽骨附着丧失,并行HE染色、TRAP染色。结果:茄尼醇可降低血浆中IL-1β、TNF-α、PGE2水平;增加SOD、GSH-Px活力,减少MDA含量。结论:茄尼醇可抑制和缓解大鼠实验性牙周炎。
Objective To investigate the effect of solanesol on oxidative stress index and inflammatory factors in plasma of experi- mental periodontitis rats. Methods 126 healthy SD rats were randomly divided into normal group （n）, model group （P）, vitamin C group （VC）, solanesol low, medium, high dose group . Intragastric administration for week 2, 4, 6, 6 rats were randomly selected to detect IL - 1β, TNF -α, PGE2, SOD, GSH - Px, MDA of their peripheral blood ; The ABL value was detected, and the HE staining and TRAP staining were performed. Results solanesol could significantly decrease the levels of IL - 1β, TNF - α, PGE2 ; the activity of GSH -Px and SOD increase more, and MDA decrease. Conclusion solanesol can inhibit the experimental periodontitis in rats.
作者
张蕊
汪显国
任晓斌
李庆华
唐军
唐丽
华一崑
刘继辉
王慧
ZHANG Rui1, WANG Xianguo2, REN Xiaobin3, LI Qinghua4, TANG Jun4, TANG Li4, HUA Yikun2, LIU Jihui2, WANG Hui2(1. Graduate School of Kunming Medical University, Kunming 650500, China; 2. HongyunHonghe Tobacco （Group） Co. , Ltd. , Kunming 650231, China; 3. Technology Center of China Tobacco Yunnan Industrial Co. , Ltd. , Kunming 650231, China; 4. Affiliated Hospital of Kunming Medical University, Kunming 650500, China)
出处
《中国民族民间医药》
2018年第6期31-40,共10页
Chinese Journal of Ethnomedicine and Ethnopharmacy
关键词
牙周炎
自由基
茄尼醇
抗氧化酶
Periodontitis
Free Radical
Solanesol
Antioxidant Enzyme
