摘要
本文用明胶为囊材将硫酸庆大霉素包成微囊,并对微囊的包囊率、主药含量、内含物的体外释放及稳定性进行了研究,提取到累积释放的三个主要参数T_(50)、T_4及m分别为24.4±0.1(min)、29.9±0.1(min)、1.81±0.03,测得包囊率为82.10±1.17%。然后,将庆大霉素微囊与醋酸洗必泰配伍制成微囊膜剂,达到缓释和延长药物疗效的目的。动物实验(家兔)表明,复方庆大霉素微囊膜对Ⅱ°烧烫伤疗效理想,只需一次性给药(贴膜)治疗。
Gelatin was used as capsule-forming agent to make microcapsules containinggentamycin sulfate. Studies were made on the capsule-forming percentage. the contentof the major drug and the in vitro release and stability of the inclusion. Threemajor parameters of accumulative release Td, T50 and M, were estimated to be29.9±0. 1 min, 24. 4±0. 1 min and 1. 81±0.03 respectively, and the capsule-formingpercentage was 82. 1±1. 17%. Combined with hibitane acetate, the prepared micro-capsule was impregnated into a medicated film to delay the drug release,prolongthe drug effects and reduce the administration frequency. Animal (rabbit) expe- riments showed that the microcapsule had an ideal effect on Ⅱ burn, in the tr-eatment of which only one sheet of the film was enough when spread over thewound.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
1991年第8期343-345,共3页
Chinese Journal of Hospital Pharmacy
关键词
复方庆大霉素微囊
微囊膜
Compound
Gentamycin microcapsule
Microcapsule-bearing film
