摘要
高糖高脂饲料喂养小鼠5周后,对其进行腹腔一次性小剂量(75mg/kg)注射STZ的方法建立2型糖尿病模型。应用水芹提取物灌胃,监测小鼠体质量、血脂四项、空腹血糖等指标,进行数据分析,考察水芹提取物对2型糖尿病小鼠成模的干预作用。水芹提取物对小鼠由高糖高脂饲料喂养引起的血脂四项指标上升有明显的抵御作用。高糖高脂饲料喂养组小鼠注射STZ后第3周成模,且成模率为80%,水芹水提物组成模率为40%,水芹醇提物组成模率为60%,且水芹提取物对2型糖尿病小鼠体质量下降有明显减缓趋势。水芹提取液对高糖高脂饲料喂养联合STZ诱导的2型糖尿病小鼠成模具有一定的干预作用。
After 5 weeks feeding, the type 2 diabetes mellitus was established by intraperitoneal injection of low-dose STZ （75 mg/kg）, to measure and statistically analyz the body Weight, blood lipid level, fastig blood glucose level. The extracs of Oenatzthe javanica can prevent the increase of blood glucose and the reduction of blood weight in STZ-induced type 2 diahets mice. In the study, the type 2 diabetic mice modle using high glucose and high fat diet and low dose STZ injection occurred at 3weeks, the achievment ratio was 80%, the aque ous extracts composition mold rate was 40%, the alcohol extracts was 60%. Therefore, Oenanthes Javanicae extracts on high glucose and high fat diet induced STZ mice with type 2 diabetes mellitus model has certain intervention effect.
作者
陈晓靓
郭晓青
吴娜怡郁
代甜甜
CHEN Xiao-jing, GUO Xiao-qing, WU Na-yi-yu ,DAI Tian-tian(Guiyang Nursing Vocational College, Guiyang, Guizhou 550081, China)
出处
《食品与机械》
CSCD
北大核心
2017年第12期135-137,共3页
Food and Machinery
基金
贵州科学技术基金项目(编号:黔科合J字[2014]2002号)
关键词
水芹
2型糖尿病
链脲佐菌素
小鼠模型
Oenanthe javanica
diabets mellitus （ type 2 ）
STZ
mice models
