摘要
目的:研究盐酸赛庚啶的晶型.方法:运用自然结晶和快速结晶方法制备盐酸赛庚啶的晶型,经X射线衍射分析法(PXRD)、差示扫描热分析法(DSC)、热重分析(TG-DTA)等方法对盐酸赛庚啶的多种晶型进行表征.结果:通过调节溶剂和结晶方式得到盐酸赛庚啶的4种晶型,经检测发现盐酸赛庚啶溶解于热的甲醇溶液自然结晶得到晶型Ⅰ,快速结晶得到晶型Ⅱ;当溶剂采用无水乙醇时得到晶型Ⅲ和Ⅳ.结论:Ⅰ~Ⅳ型盐酸赛庚啶的理化性质存在明显差异,最终以甲醇为溶剂,快速结晶制备出了新晶形Ⅱ,晶形Ⅱ熔点最高、融化吸收热量大,具有较好的稳定性,并且晶型纯度高.
Objective： To study the polymorphism of cyproheptadine hydrochloride. Methods： The crystalline forms of cyproheptadine hydrochloride were prepared by natural crystallization and rapid crystallization. The various crystal forms of eyproheptadine hydrochloride were characterized by X-ray diffraction, differential scanning calorimetry and thermogravimetry. Results： Cyproheptiadine was dissolved in hot methanol solution for natural crystallization to obtain Form I , rapid crystallization to obtain Form II, in anhydrous ethanol to obtain Form Ⅲ and IV. Conclusion： The physieoehemieal properties of I - IV cyproheptadine were significantly different from each other. Crystal form IIshowed the lowest melting point and the water content conformed to pharmacopoeia standards.
作者
胡春霞
王一飞
蒲含林
HU Chunixa;WANG Yifei;PU Hanlin(Department of Cell Biology, School of Life Science and Technology, Jinan University, Guangzhou 510632, China)
出处
《暨南大学学报（自然科学与医学版）》
CAS
CSCD
北大核心
2018年第1期67-72,共6页
Journal of Jinan University(Natural Science & Medicine Edition)
基金
国家自然科学基金项目(81274170)
关键词
药物晶型
盐酸赛庚啶
X射线衍射
差示扫描量热法
表征
crystallization
cyproheptadine hydrochloride
X ray diffraction
differentialscanning calorimetry
characterization
