摘要
目的:探讨中性粒细胞与淋巴细胞比值(neutrophil to lymphocyte ratio,NLR)对急性脑梗死(acute cerebral infarction,ACI)溶栓患者预后的预测价值.方法:回顾性连续纳入的急性脑梗死溶栓患者123例,其中男80例,女43例.根据改良Rankin量表评分标准,分为预后良好组(71例)及预后不良组(52例).比较2组患者的临床资料并进行多元Logistics回归分析,采用受试者工作特征(ROC)曲线评价入院时NLR水平,对急性脑梗死溶栓患者进行预后的评估.结果:2组在年龄、高血压、房顫、入院时美国国立卫生研究院卒中量表(NIHSS)评分、溶栓后1hNIHSS评分、血糖、白细胞计数、中性粒细胞计数、淋巴细胞计数及NLR水平方面比较,差异有统计学意义(P<0.05).多因素Logistics回归分析显示,中性粒细胞计数、NLR、白细胞计数、溶栓后1hNIHSS评分是ACI溶栓患者预后的独立危险因素,预测曲线下面积分别是0.632、0.701、0.685、0.867.入院时NLR预测急性脑梗死溶栓患者预后的最佳界值为3.375,其敏感度和特异度分别是59.6%和81.7%.结论:入院时NLR对急性脑梗死溶栓患者预后有一定的预测价值.
Objective：To investigate the prognostic value of neutrophil and lymphocyte ratios （NLR） in patients with acute cerebral infarction with thrombolytie therapy. Methods： One hundred and twenty- three consecutive patients with acute cerebral infarction with thrombolytic therapy were enrolled retrospectively,including 80 males and 43 females. The patients with thrombolytie therapy were attacked by modified Rankin Scale（mRS） score, and all cases were divided into good prognosis group （n = 71 ） and poor prognosis group （ n -- 52 ）. The clinical data of the two groups were compared and the muli- variable logistics regression analysis was used. The receiver operating characteristic curve （ROC） wasused to evaluate the predictive effect of the NLR level on patients with thrombolytic therapy in acute cerebral infarction. Results： There were statistically significant differences between the two groups on age, history of high blood pressure, atrial fibrillation, NIHSS score on admission, one hour NIHSS score after thrombolysis, blood glucose, leukocyte counts, neutrophil counts, and lymphocyte counts and NLR （all P 〈 0.05 ）. The Logistics regression analysis showed that the neutrophil counts, NLR level on admission,leukocyte counts, one hour NIHSS score after thrombolysis were independent risk factors for the prognosis in patients with thrombolytic therapy in acute cerebral infarction, and they predicted the area under the curve was respectively 0. 632,0. 701,0. 685 and 0. 867. The optimal cut-off value of the NLR level on admission was 3.375 ,with a sensitivity of 59.6% and a specificity of 81.7% for predicting patients with thrombolytic therapy in acute cerebral infarction. Conclusion：The NLR level on admission had a certain predictive value in the prognosis in patients with thrombolytic therapy in acute cerebral infarction.
作者
王莹莹
张健芳
蒋亚斌
黄立安
WANG Yingying;ZHANG Jianfang;JIANG Yabinl;HUANG Lian(Department of Emergency;Department of Neurology, the First Affiliated Hospital, Jinan university, Guangzhou 510630, China)
出处
《暨南大学学报（自然科学与医学版）》
CAS
CSCD
北大核心
2018年第1期35-40,共6页
Journal of Jinan University(Natural Science & Medicine Edition)
基金
广东省科技计划项目(2014A020212216)
关键词
中性粒细胞
淋巴细胞
急性脑梗死
预后
neutrophils
leukocytes
acute cerebral infarction
prognosis
